Dunn S, Maguen E, Rao N A
Cornea. 1985;4(3):189-93.
A multifocal progressive infiltration of a corneal graft, which simulated a mycotic keratitis but was repeatedly negative on culture and unresponsive to antibacterial and antifungal therapy, was found upon regrafting to consist primarily of Gram-positive cocci. This bacterial colonization of the corneal graft was associated with epithelialized suture tracks and minimal inflammatory response. The immunosuppressive and bacteriostatic effects of chronic postsurgery low dose steroid and antimicrobial therapy may have played a role in the development of this atypical bacterial infiltrate.
一例角膜移植片出现多灶性进行性浸润，其表现类似真菌性角膜炎，但培养结果反复呈阴性，且对抗菌和抗真菌治疗无反应。再次移植时发现主要由革兰氏阳性球菌构成。这种角膜移植片的细菌定植与上皮化的缝线通道及轻微炎症反应有关。术后长期低剂量类固醇和抗菌治疗的免疫抑制及抑菌作用可能在这种非典型细菌浸润的发生过程中起了作用。
