人体在缺血、缺氧和局部低温期间皮肤pH值的微电极测量。
Micro-electrode measurement of skin pH in humans during ischaemia, hypoxia and local hypothermia.
作者信息
Harrison D K, Walker W F
出版信息
J Physiol. 1979 Jun;291:339-50. doi: 10.1113/jphysiol.1979.sp012817.
Abstract
- The extracellular pH value in the dermis of human skin (skin pH) was measured in vivo using glass micro-electrodes. They were found to be both reliable and accurate. 2. The mean value of skin pH measured in the legs of forty different volunteers was found to be pH 7.54 +/- 0.09 (S.D.). No difference in skin pH was observed between males and females, or in different regions of the limb. 3. Local reductions in skin surface temperature in ten subjects caused an increase of pH 0.023 +/- 0.007 per degree C fall. 4. A 20 min period of tourniquet ischaemia in twenty volunteers induced a fall in skin pH of 0.13 +/- 0.05 units. 5. Hyperventilation during a 10 min period of breathing 10% O2 in N2 caused an increase of pH 0.04 +/- 0.02 in the skin of healthy subjects. 6. Skin pH fell to a value 0.02 +/- 0.02 units below normal 10 min after the hypoxic period, suggesting the presence of excess lactate. 7. Skin pH results compared well with blood gases and pH values of arterialized samples taken during hypoxia. 8. It was concluded that the system was suitable for clinical trials.
摘要
- 使用玻璃微电极在人体皮肤真皮层中对细胞外pH值（皮肤pH值）进行了活体测量。结果发现这些微电极既可靠又准确。2. 对40名不同志愿者腿部测量的皮肤pH值平均值为pH 7.54±0.09（标准差）。未观察到男性与女性之间或肢体不同部位的皮肤pH值存在差异。3. 10名受试者皮肤表面温度的局部降低导致每降低1摄氏度pH值升高0.023±0.007。4. 20名志愿者进行20分钟的止血带缺血处理后，皮肤pH值下降了0.13±0.05个单位。5. 在10分钟内呼吸含10%氧气的氮气进行过度通气，导致健康受试者皮肤pH值升高0.04±0.02。6. 缺氧期10分钟后，皮肤pH值降至比正常水平低0.02±0.02个单位，表明存在过量乳酸。7. 皮肤pH值结果与缺氧期间采集的动脉化样本的血气和pH值相比良好。8. 得出的结论是，该系统适用于临床试验。
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