Amorim D S
Heart Vessels Suppl. 1985;1:236-9. doi: 10.1007/BF02072401.
An experimental model embodies an evaluation procedure that helps the investigator to choose between possible alternatives. In this paper, consideration is given to a variety of aspects related to the host-parasite relationship in Trypanosoma cruzi infection and disease. Although several animal species have been used, there is still a lack of consistent experimental studies. A few examples of investigations mainly in dogs, monkeys, and rabbits are briefly described, showing the diversity of methodological approaches and, therefore, the difficulty experienced in comparing results and interpretations. Emphasis was given to the need for a suitable model presenting all possible stage of the infection as seen in man, as well as the functional and organic disorders commonly seen in this disease. The alterations of the autonomic nervous system involving the heart and other organs in Chagas' disease was stressed.
一个实验模型体现了一种评估程序，该程序有助于研究者在可能的选择之间做出抉择。本文考虑了与克氏锥虫感染和疾病中宿主 - 寄生虫关系相关的各个方面。尽管已经使用了几种动物物种，但仍缺乏连贯的实验研究。简要描述了一些主要在狗、猴子和兔子身上进行的研究实例，展示了方法学方法的多样性，因此也展示了在比较结果和解释时所遇到的困难。强调需要一个合适的模型，该模型要呈现出人类感染中所有可能的阶段，以及这种疾病中常见的功能和器官紊乱。文中着重阐述了恰加斯病中涉及心脏和其他器官的自主神经系统的改变。
