Safini Fatima, Amaoui Bouchra, Oqbani Kenza, Abbaoui Sanae, Semghouli Slimane
Department of Radiation Therapy, Souss-Massa University Hospital, Agadir, MAR.
Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, MAR.
Cureus. 2024 Jul 21;16(7):e65033. doi: 10.7759/cureus.65033. eCollection 2024 Jul.
Low-dose radiotherapy (LD-RT) has historically been used to treat severe bacterial and viral pneumonia due to its immunomodulatory properties. However, this technique has been delayed since the advent of antibiotics and the carcinogenic risk associated with radiation therapy. Currently, it represents an alternative therapeutic in the SARS-CoV-2 pandemic which leads sometimes to fatal pneumonia, especially given the limited availability of effective treatments for severe forms of pneumonia. Numerous in vitro and in vivo studies have demonstrated the anti-inflammatory effect of LD-RT and have reported clinical and biological improvement in patients with severe pneumonia. In this literature review, we report the data and results of various published clinical trials.
低剂量放疗（LD-RT）因其免疫调节特性，在历史上一直被用于治疗严重的细菌性和病毒性肺炎。然而，自抗生素问世以及放疗相关致癌风险出现以来，这项技术的应用有所延迟。目前，在新型冠状病毒肺炎（SARS-CoV-2）大流行中，它成为一种替代疗法，这种大流行有时会导致致命性肺炎，特别是考虑到针对重症肺炎的有效治疗方法有限。大量的体外和体内研究已经证明了低剂量放疗的抗炎作用，并报告了重症肺炎患者的临床和生物学改善情况。在这篇文献综述中，我们报告了各种已发表临床试验的数据和结果。
