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一例以胸骨肿块为表现的多发性骨髓瘤非典型病例报告

A Case Report of the Atypical Presentation of Multiple Myeloma Manifesting as a Sternal Mass.

作者信息

Kaushik Himanshi, Manuja Nishtha, Devde Kanchan D, Dongre Amol

机构信息

Department of Medical Oncology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, IND.

Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, IND.

出版信息

Cureus. 2024 Jul 20;16(7):e65004. doi: 10.7759/cureus.65004. eCollection 2024 Jul.

DOI:10.7759/cureus.65004
PMID:39165445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11335064/
Abstract

The diagnosis of multiple myeloma (MM) is made based on the presence of either marrow clonal plasma cells > 10% or an extramedullary or bony plasmacytoma confirmed by biopsy. Additionally, at least one of the SLiM (sixty years, light chain ratio, magnetic resonance imaging)-CRAB (calcium elevation, renal insufficiency, anemia, and bone lesions) myeloma-defining events must be present. MM typically presents with symptoms such as fatigue due to anemia, kidney failure, hypercalcemia, and bone pain. It is uncommon, though, for MM to manifest as a single bone mass. We report the case of a 65-year-old male who did not fit the criteria for solitary bone plasmacytoma and presented with an unusual sternal tumor. The patient was diagnosed with MM despite not having any of the traditional symptoms such as low back pain, weight loss, anemia, or hypercalcemia. The diagnosis was based on a bone marrow examination, which showed 50% plasma cells. Radiation therapy and systemic chemotherapy were then used to treat him. The patient's symptoms, radiological findings, and biopsy results are described in detail, emphasizing the difficulty and intricacy of correctly diagnosing this uncommon manifestation of MM. This case highlights the need for a comprehensive and multidisciplinary strategy to diagnose and treat atypical presentations of MM, making sure that all possible diagnostic pathways are investigated in order to achieve accurate and timely diagnosis and treatment.

摘要

多发性骨髓瘤(MM)的诊断基于骨髓中克隆性浆细胞>10%,或经活检证实的髓外或骨浆细胞瘤的存在。此外,必须至少出现一项SLiM(年龄≥60岁、轻链比例、磁共振成像)-CRAB(血钙升高、肾功能不全、贫血和骨病变)骨髓瘤定义事件。MM通常表现为因贫血、肾衰竭、高钙血症和骨痛等症状导致的疲劳。不过,MM表现为单一骨肿块并不常见。我们报告一例65岁男性病例,该患者不符合孤立性骨浆细胞瘤的标准,表现为不寻常的胸骨肿瘤。尽管该患者没有任何传统症状,如腰痛、体重减轻、贫血或高钙血症,但仍被诊断为MM。诊断基于骨髓检查,结果显示浆细胞占50%。随后对其进行了放射治疗和全身化疗。详细描述了患者的症状、影像学检查结果和活检结果,强调了正确诊断MM这种罕见表现形式的难度和复杂性。该病例突出了采用全面且多学科策略来诊断和治疗MM非典型表现的必要性,确保对所有可能的诊断途径进行调查,以实现准确、及时的诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d14/11335064/f81f607c205f/cureus-0016-00000065004-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d14/11335064/66b7094a5b2b/cureus-0016-00000065004-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d14/11335064/47b81a6a45d4/cureus-0016-00000065004-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d14/11335064/f81f607c205f/cureus-0016-00000065004-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d14/11335064/66b7094a5b2b/cureus-0016-00000065004-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d14/11335064/47b81a6a45d4/cureus-0016-00000065004-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d14/11335064/f81f607c205f/cureus-0016-00000065004-i03.jpg

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本文引用的文献

1
Multiple Myeloma, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.多发性骨髓瘤,第 2.2024 版,NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2023 Dec;21(12):1281-1301. doi: 10.6004/jnccn.2023.0061.
2
A Rare Case of Solitary Plasmacytoma Arising From the Sternum.一例罕见的起源于胸骨的孤立性浆细胞瘤
Cureus. 2022 Apr 4;14(4):e23819. doi: 10.7759/cureus.23819. eCollection 2022 Apr.
3
Epidemiology, Staging, and Management of Multiple Myeloma.多发性骨髓瘤的流行病学、分期和治疗。
Med Sci (Basel). 2021 Jan 20;9(1):3. doi: 10.3390/medsci9010003.
4
An atypical presentation of multiple myeloma in a young patient with pathological fracture.一名年轻患者因病理性骨折出现多发性骨髓瘤的非典型表现。
J Family Med Prim Care. 2020 Jun 30;9(6):3154-3156. doi: 10.4103/jfmpc.jfmpc_343_20. eCollection 2020 Jun.
5
Solitary plasmacytoma of the occipital bone: a case report.枕骨孤立性浆细胞瘤:一例报告
J Int Med Res. 2020 Aug;48(8):300060520914817. doi: 10.1177/0300060520914817.
6
Multiple myeloma: managing a complex blood cancer.多发性骨髓瘤:应对一种复杂的血癌。
Br J Nurs. 2016 Sep 8;25(16):S18-28. doi: 10.12968/bjon.2016.25.S18.
7
The Diagnosis and Treatment of Multiple Myeloma.多发性骨髓瘤的诊断与治疗
Dtsch Arztebl Int. 2016 Jul 11;113(27-28):470-6. doi: 10.3238/arztebl.2016.0470.
8
Radiation Therapy For The Solitary Plasmacytoma.孤立性浆细胞瘤的放射治疗
Turk J Haematol. 2010 Jun 5;27(2):57-61. doi: 10.5152/tjh.2010.01.
9
Multiple Myeloma: Diagnosis and Treatment.多发性骨髓瘤:诊断与治疗
Mayo Clin Proc. 2016 Jan;91(1):101-19. doi: 10.1016/j.mayocp.2015.11.007.
10
Sub cuteneous swelling as the first clinical manifestation of small cell carcinoma of lung.皮下肿胀作为肺癌小细胞癌的首发临床表现。
Clin Pract. 2012 Jun 7;2(3):e62. doi: 10.4081/cp.2012.e62. eCollection 2012 May 29.