Kotlarz Payton N, Garcia Gustavo, Rosario Manuel, Vargas Ian, Cai Zhen Kevin
Internal Medicine, Florida State University College of Medicine, Tallahassee, USA.
Internal Medicine, Florida State University College of Medicine, Sarasota Memorial Hospital, Sarasota, USA.
Cureus. 2024 Jul 21;16(7):e65042. doi: 10.7759/cureus.65042. eCollection 2024 Jul.
Waldenström's macroglobulinemia (WM) is a B-cell non-Hodgkin's lymphoma characterized by clonal IgM-secreting lymphoplasmacytic cell proliferation. Bing-Neel syndrome (BNS) is a rare complication of WM that results in the infiltration of the central nervous system (CNS) with IgM-secreting lymphoplasmacytic cells. This case study presents a 75-year-old Caucasian male with a history of WM and Agent Orange exposure who ultimately was diagnosed with BNS. This patient posed unique diagnostic challenges as the patient experienced clinical symptoms despite the absence of MRI abnormalities and therapeutic challenges.
华氏巨球蛋白血症（WM）是一种B细胞非霍奇金淋巴瘤，其特征为克隆性分泌IgM的淋巴浆细胞增殖。宾-尼尔综合征（BNS）是WM的一种罕见并发症，可导致分泌IgM的淋巴浆细胞浸润中枢神经系统（CNS）。本病例研究介绍了一名75岁的白种男性，有WM病史且接触过橙剂，最终被诊断为BNS。该患者带来了独特的诊断挑战，因为尽管MRI检查无异常，但患者仍出现了临床症状，同时也带来了治疗挑战。
