Buyukmurat Neslihan, Karadag Erdi, Ozbek Hanefi
Department of Administration, University of Health Sciences, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkiye.
Department of Medical School Administration, Izmir Bakircay University, Izmir, Turkiye.
North Clin Istanb. 2024 Jul 31;11(4):271-276. doi: 10.14744/nci.2024.87405. eCollection 2024.
The purpose of this study was to assess the influence of latanoprost on choroidal thickness in patients with newly diagnosed primary open-angle glaucoma using Swept-Source Optical Coherence Tomography (SS-OCT).
The retrospective, non-randomized study comprised 40 newly diagnosed primary open-angle glaucoma patients receiving latanoprost therapy (Group 1). Additionally, 40 age- and sex-matched healthy subjects served as the control group (Group 2). Using SS-OCT, measurements of subfoveal, horizontal temporal, and horizontal nasal quadrants choroidal thickness, as well as intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) thickness values, were collected at baseline and after 1 month for both groups.
The mean age was 39.8±4.15 years (range: 18-45 years) in group 1 and 41.67±7.95 years (range: 18-45 years) in group 2 (p>0.05). The mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant prior to latanoprost therapy were 263.57±84.23 μm, 233.05±80.08 μm, and 219.52±83.28 μm in the group 1 whereas 278.9±93.88 μm, 243.8±73.37 μm and 209.85±92.92 μm in the group 2. After latanoprost therapy, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant, and horizontal nasal quadrant changed significantly to 299.77±41.29 μm, 269.9±43.80 μm, and 261.32±45.60 μm in the group 1 (p=0.02, p=0.016, and p=0.012, respectively) (Table 1). However, the mean choroidal thickness in the subfoveal area, horizontal temporal quadrant and horizontal nasal quadrant in group 2 changed not significant and was 279.25±103.37 μm, 246.42±87.07 μm and 203.62±106.74 μm, respectively (p=0.4, p=0.5 and p=0.9, respectively). The mean IOP decreased significantly in group 1 (p=0.000) but did not change significantly in group 2 (p=0.153). There was no difference in RNFL thickness values at baseline and 1 st month in group 1 and group 2 (p>0.05).
Topical latanoprost may increase choroidal thickness. Swept Source-OCT may contribute to our understanding of the actions of latanoprost on choroidal thickness.
本研究旨在使用扫频光学相干断层扫描（SS-OCT）评估拉坦前列素对新诊断的原发性开角型青光眼患者脉络膜厚度的影响。
这项回顾性、非随机研究包括40例接受拉坦前列素治疗的新诊断原发性开角型青光眼患者（第1组）。另外，40例年龄和性别匹配的健康受试者作为对照组（第2组）。使用SS-OCT，在基线和1个月后收集两组的黄斑中心凹下、颞侧水平象限和鼻侧水平象限的脉络膜厚度测量值，以及眼压（IOP）和视网膜神经纤维层（RNFL）厚度值。
第1组的平均年龄为39.8±4.15岁（范围：18 - 45岁），第2组为41.67±7.95岁（范围：18 - 45岁）（p>0.05）。拉坦前列素治疗前，第1组黄斑中心凹下区域、颞侧水平象限和鼻侧水平象限的平均脉络膜厚度分别为263.57±84.23μm、233.05±80.08μm和219.52±83.28μm，而第2组分别为278.9±93.88μm、243.8±73.37μm和209.85±92.92μm。拉坦前列素治疗后，第1组黄斑中心凹下区域、颞侧水平象限和鼻侧水平象限的平均脉络膜厚度显著变化为299.77±41.29μm、269.9±43.80μm和261.32±45.60μm（分别为p = 0.02、p = 0.016和p = 0.012）（表1）。然而，第2组黄斑中心凹下区域、颞侧水平象限和鼻侧水平象限的平均脉络膜厚度变化不显著，分别为279.25±103.37μm、246.42±87.07μm和203.62±106.74μm（分别为p = 0.4、p = 0.5和p = 0.9）。第1组的平均眼压显著降低（p = 0.000），但第2组无显著变化（p = 0.153）。第1组和第2组在基线和第1个月时RNFL厚度值无差异（p>0.05）。
局部应用拉坦前列素可能增加脉络膜厚度。扫频光学相干断层扫描可能有助于我们理解拉坦前列素对脉络膜厚度的作用。
