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与局部应用拉坦前列素治疗相关的中心性浆液性脉络膜视网膜病变。

Central serous chorioretinopathy associated with topical latanoprost therapy.

出版信息

Ocul Immunol Inflamm. 2011 Dec;19(6):453-5. doi: 10.3109/09273948.2011.619680.

Abstract

PURPOSE

To report a case of central serous chorioretinopathy (CSC) as a possible complication of latanoprost treatment.

METHODS

A 65-year-old woman presented with a 1-week history of blurred vision and metamorphopsia in her right eye. She was previously diagnosed with unilateral glaucoma, and treatment was initiated with topical latanoprost 0.005% for the right eye. The symptoms occurred 1 month after initiation of glaucoma treatment.

RESULTS

Visual acuity (VA) of the patient had reduced to 20/50 in right eye. Fluorescein angiography revealed a focal RPE leak near to the fovea with neurosensory detachment due to CSC, which was confirmed by optical coherence tomography. After cessation of the therapy, her clinical and morphological status improved spontaneously. The neurosensory detachment resolved almost completely and VA improved to 20/20 simultaneously.

CONCLUSIONS

The authors report the first case of CSC associated with latonoprost therapy. This case demonstrates that topical latanoprost may lead to the development of CSC.

摘要

目的

报告 1 例可能与拉坦前列素治疗相关的中心性浆液性脉络膜视网膜病变(CSC)。

方法

1 例 65 岁女性,右眼视力模糊伴视物变形 1 周就诊。患者曾被诊断为单侧青光眼,开始给予右眼局部滴用 0.005%拉坦前列素治疗。症状出现在开始青光眼治疗后 1 个月。

结果

右眼视力(VA)下降至 20/50。荧光素眼底血管造影显示右眼黄斑旁有一处 RPE 渗漏,伴有 CSC 导致的神经感觉层脱离,这一结果通过光学相干断层扫描得到证实。停用治疗后,她的临床和形态学状况自发改善。神经感觉层脱离几乎完全缓解,同时 VA 提高至 20/20。

结论

作者报告首例与拉坦前列素治疗相关的 CSC。该病例表明,局部应用拉坦前列素可能导致 CSC 的发生。

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