Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy.
Optometry and Visual Sciences, City, University of London, London, UK.
Transl Vis Sci Technol. 2022 Jun 1;11(6):27. doi: 10.1167/tvst.11.6.27.
To compare peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGCIPL) thickness measurements obtained with spectral domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT) using an OCT-angiography scanning protocol, and their ability to distinguish among patients with glaucoma, glaucoma suspects (GS), and healthy controls (HC).
Cross-sectional study of 196 eyes (81 glaucoma, 48 GS, and 67 HC) of 119 participants. Participants underwent peripapillary and macular OCT with SD-OCT and SS-OCT. Parameters of interest were average and sector-wise pRNFL and mGCIPL thickness. Inter-device agreement was investigated with Bland-Altman statistics. Conversion formulas were developed with linear regression. Diagnostic performances were evaluated with area under the receiver operating characteristic curves.
Both SD-OCT and SS-OCT detected a significant pRNFL and mGCIPL thinning in glaucoma patients compared to HC and GS for almost all study sectors. A strong linear relationship between the two devices was present for all quadrants/sectors (R2 ≥ 0.81, P < 0.001), except for the nasal (R2 = 0.49, P < 0.001) and temporal (R2 = 0.62, P < 0.001) pRNFL quadrants. SD-OCT and SS-OCT measurements had a proportional bias, which could be removed with conversion formulas. Overall, the two devices showed similar diagnostic abilities.
Thickness values obtained with SD-OCT and SS-OCT are not directly interchangeable but potentially interconvertible. Both devices have a similar ability to discriminate glaucoma patients from GS and healthy subjects.
OCT-Angiography scans can be reliably used to obtain structural metrics in glaucoma patients.
比较使用光相干断层扫描血管造影（OCTA）扫描协议获得的光谱域光学相干断层扫描（SD-OCT）和扫频源光学相干断层扫描（SS-OCT）的视盘周围视网膜神经纤维层（pRNFL）和黄斑神经节细胞内丛状层（mGCIPL）厚度测量值，以及它们在鉴别青光眼患者、青光眼疑似患者（GS）和健康对照（HC）方面的能力。
本研究纳入了 119 名参与者的 196 只眼（81 只青光眼、48 只 GS 和 67 只 HC），进行了视盘周围和黄斑 OCT 检查，包括 SD-OCT 和 SS-OCT。关注的参数包括平均和扇形 pRNFL 和 mGCIPL 厚度。采用 Bland-Altman 统计方法评估设备间的一致性。通过线性回归建立转换公式。采用受试者工作特征曲线下面积评估诊断性能。
与 HC 和 GS 相比，SD-OCT 和 SS-OCT 几乎在所有研究象限中都检测到青光眼患者的 pRNFL 和 mGCIPL 变薄。两种设备之间存在很强的线性关系（所有象限/区域 R2≥0.81，P<0.001），除了鼻侧（R2=0.49，P<0.001）和颞侧（R2=0.62，P<0.001）pRNFL 象限。SD-OCT 和 SS-OCT 测量值存在比例偏差，可以通过转换公式消除。总的来说，两种设备具有相似的诊断能力。
SD-OCT 和 SS-OCT 获得的厚度值不能直接互换，但可以通过转换公式相互转换。两种设备在鉴别青光眼患者与 GS 和健康受试者方面具有相似的能力。
杨雪燕
