Ebe Angel Mae A, Gucila Chriszle Anne T, Esponilla Aj G, Canja Jayson B, Gabucan Von Jay Maico G
College of Pharmacy and Chemistry, University of the Immaculate Conception, Davao City 8000, Philippines.
Innov Pharm. 2024 May 31;15(2). doi: 10.24926/iip.v15i2.6228. eCollection 2024.
: Evaluating the adherence to HIV Pre-Exposure Prophylaxis (PrEP) is essential for increasing its utilization and decreasing the risk of HIV transmission among Davao City's vulnerable groups. : The research method utilized in the study is a quantitative, retrospective, descriptive research design. This method was employed to retrospectively review the de-identified data, which involved the fill and refill dates of PrEP and tablets supplied, to calculate the Proportion of Days Covered (PDC) among individuals in Davao City from January 2021 to December 2023. The study also included some demographic characteristics such as age and gender. : From 178 data entries collected, the age group of 25 to 34 years old was found to have the highest HIV PrEP use (52.25%), followed by those between 18 to 24 (30.90%), 35 to 44 (13.48%), and 45 years old and older (3.37%). Out of 178, only 2 clients were female. Furthermore, 73.60% of the 178 entries in the pharmacy records were identified to be taking PrEP daily. Descriptive statistics showed that the frequency of adherent clients across the years were 36.36%, 44.74% and 38.46%, respectively. Furthermore, the average PDC through the years was found to be 70.13%, 80.48%, and 72.8%. Age did not significantly affect adherence to PrEP during the years investigated (p-values > 0.05). : Adherence to PrEP improved consistently in 2022 but declined in 2023, showing erratic adherence rates. Furthermore, adherence to HIV PrEP in Davao City was found to be suboptimal and while there are clients who are adherent, many are not. The results emphasize the need for targeted interventions and suggest that other socio-behavioral factors may play a role in this. To improve adherence and prevent HIV contractions, both short-term actions like public education campaigns about HIV PrEP and long-term plans like incorporating PrEP into the community pharmacies can be contributive.
评估对艾滋病毒暴露前预防（PrEP）的依从性对于提高其使用率和降低达沃市弱势群体中的艾滋病毒传播风险至关重要。
本研究采用的研究方法是定量、回顾性、描述性研究设计。该方法用于回顾性审查去识别化的数据，其中包括PrEP的填充和再填充日期以及提供的药片数量，以计算2021年1月至2023年12月期间达沃市个体的药物覆盖天数比例（PDC）。该研究还包括一些人口统计学特征，如年龄和性别。
在收集的178条数据记录中，25至34岁年龄组的艾滋病毒PrEP使用率最高（52.25%），其次是18至24岁的人群（30.90%）、35至44岁的人群（13.48%）以及45岁及以上的人群（3.37%）。在178人中，只有2名女性客户。此外，药房记录中的178条记录中有73.60%被确定为每天服用PrEP。描述性统计显示，各年份依从性客户的频率分别为36.36%、44.74%和38.46%。此外，各年份的平均PDC分别为70.13%、80.48%和72.8%。在所调查的年份中，年龄对PrEP的依从性没有显著影响（p值>0.05）。
2022年对PrEP的依从性持续改善，但在2023年有所下降，显示出不稳定的依从率。此外，发现达沃市对艾滋病毒PrEP的依从性不理想，虽然有一些客户依从，但许多人并不依从。结果强调了有针对性干预的必要性，并表明其他社会行为因素可能在其中起作用。为了提高依从性并预防艾滋病毒感染，开展关于艾滋病毒PrEP的公众教育活动等短期行动以及将PrEP纳入社区药房等长期计划都可能有所帮助。
