在胎盘植入谱系疾病患者的胎盘、脐带和母血清中表达的沉默调节蛋白 1。
Expression of sirtuins 1 in placenta, umbilical cord, and maternal serum of patients diagnosed with placenta accreta spectrum.
机构信息
Inonu University, Faculty of Science and Art, Department of Molecular Biology and Genetics - Malatya, Turkey.
Dicle University, Department of Obstetrics and Gynecology -Diyarbakır, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2024 Aug 16;70(8):e20240314. doi: 10.1590/1806-9282.20240314. eCollection 2024.
OBJECTIVE
Placenta accreta spectrum (PAS) is defined as the attachment of the placenta to the uterine wall in varying degrees. However, the studies have explored that the underlying molecular mechanisms of the PAS are very limited. Sirtuins 1 (SIRT1) is associated with placental development by controlling trophoblast cell invasion and remodeling of spiral arteries. We aimed to determine the expression level of SIRT1 in placentas, and maternal and umbilical cord serum of patients with PAS.
METHODS
In total, 30 individuals in control, 20 patients in the placenta previa group, and 30 patients in the PAS group were included in this study. The expression levels of SIRT1 in the placentas were determined by Western blot and immunohistochemistry. Serum levels of SIRT1 in maternal and umbilical cord blood were determined by ELISA.
RESULTS
SIRT1 was significantly lower in placentas of the PAS. However, maternal and umbilical cord serum samples were not significantly different between groups.
CONCLUSION
SIRT1 may play an important role in the pathogenesis of the PAS.
目的
胎盘部位过度增生谱（PAS）定义为胎盘在不同程度上附着于子宫壁。然而，已有研究表明，PAS 的潜在分子机制非常有限。Sirtuins 1（SIRT1）通过控制滋养细胞侵袭和螺旋动脉重塑与胎盘发育有关。我们旨在确定 SIRT1 在胎盘、患有 PAS 的产妇和脐血血清中的表达水平。
方法
本研究共纳入 30 名对照组、20 名前置胎盘组和 30 名 PAS 组患者。通过 Western blot 和免疫组织化学法测定胎盘组织中 SIRT1 的表达水平。通过 ELISA 法测定产妇和脐血血清中 SIRT1 的水平。
结果
PAS 患者的胎盘组织中 SIRT1 明显降低。然而，各组产妇和脐血血清样本之间无显著差异。
结论
SIRT1 可能在 PAS 的发病机制中起重要作用。
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