Sirtuin 2 和 7 在胎盘植入谱中的表达。
Expression of sirtuin 2 and 7 in placenta accreta spectrum.
机构信息
İnönü University, Faculty of Science and Art, Department of Molecular Biology and Genetics - Malatya, Turkey.
Dicle University, Department of Obstetrics and Gynecology - Diyarbakir, Turkey.
出版信息
Rev Assoc Med Bras (1992). 2023 Aug 14;69(8):e20230360. doi: 10.1590/1806-9282.20230360. eCollection 2023.
OBJECTIVE
This study aimed to investigate the expression levels of sirtuin 2 and sirtuin 7 in the placenta accreta spectrum to reveal their role in its pathogenesis.
METHODS
A total of 30 placenta accreta spectrum, 20 placenta previa, and 30 controls were experienced. The sirtuin 2 and sirtuin 7 expression levels in the placentas of these groups were determined by Western blot. sirtuin 2 and sirtuin 7 serum levels in the maternal and fetal cord blood were examined by enzyme-linked immunosorbent assay.
RESULTS
It was found that sirtuin 7 in placenta accreta spectrum was significantly lower in the placenta compared to the control and placenta previa groups (p<0.05). However, a significant difference was not observed between the sirtuin 2 and sirtuin 7 levels in the maternal and fetal cord serum samples of those three groups (p>0.05).
CONCLUSION
Sirtuin 7 may play an important role in the formation of placenta accreta spectrum. The effect of decreased expression of sirtuin 7 might be tissue-dependent in the placenta accreta spectrum and needs to be investigated further.
目的
本研究旨在探讨沉默信息调节因子 2（sirtuin 2）和沉默信息调节因子 7（sirtuin 7）在胎盘植入谱中的表达水平，以揭示其在发病机制中的作用。
方法
共纳入 30 例胎盘植入谱、20 例前置胎盘和 30 例对照组患者。采用 Western blot 检测各组胎盘组织中 sirtuin 2 和 sirtuin 7 的表达水平，采用酶联免疫吸附试验检测母血和胎血中 sirtuin 2 和 sirtuin 7 的血清水平。
结果
与对照组和前置胎盘组相比，胎盘植入谱组的 sirtuin 7 在胎盘组织中的表达显著降低（p<0.05）。然而，三组母血和胎血中 sirtuin 2 和 sirtuin 7 的水平差异无统计学意义（p>0.05）。
结论
sirtuin 7 可能在胎盘植入谱的形成中发挥重要作用。sirtuin 7 表达降低的影响可能在胎盘植入谱中具有组织依赖性，需要进一步研究。
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