Beard Jessica C, Wang Chi-Hsien, Sridharan Arun, Croy Robert G, Essigmann John M, Swager Timothy M
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Department of Biological Engineering and Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
ACS Sens. 2024 Sep 27;9(9):4655-4661. doi: 10.1021/acssensors.4c00927. Epub 2024 Aug 21.
-Nitrosamines are contaminants found throughout the environment, including in drinking water, and many nitrosamines are likely potent carcinogens. Correspondingly, there is a need for rapid and cost-effective in-field detection methods that can provide timely information about their contamination levels in water. This study details a colorimetric assay for detecting aqueous -nitrosodimethylamine (NDMA) by photochemical nitrosation of a commercial naphtholsulfonate, to offer an attractive alternative to traditional laboratory-based analysis. The resulting naphthoquinone-oxime coordinates to aqueous iron(II) ions to form a green complex, allowing for direct visual detection. Characterization via Mössbauer and electron paramagnetic resonance (EPR) spectroscopy, alongside single-crystal structure determination, provides comprehensive structure information on the iron indicator complex. Optimization of detection conditions, including UV irradiation and response times, led to an improved colorimetric detection method with a limit of detection of 0.66 ppm for NDMA. The practical applicability and selectivity of this colorimetric detection scheme make it a promising candidate for the development of field-deployable sensors for NDMA in environmental water samples.
亚硝胺是在包括饮用水在内的整个环境中都能发现的污染物，许多亚硝胺可能是强效致癌物。相应地，需要快速且经济高效的现场检测方法，以便能够及时提供有关水中亚硝胺污染水平的信息。本研究详细介绍了一种比色测定法，通过对一种商用萘酚磺酸盐进行光化学亚硝化来检测水中的亚硝基二甲胺（NDMA），为传统的基于实验室的分析提供了一种有吸引力的替代方法。生成的萘醌肟与水合铁（II）离子配位形成绿色络合物，从而实现直接目视检测。通过穆斯堡尔谱和电子顺磁共振（EPR）光谱进行表征，以及单晶结构测定，提供了关于铁指示剂络合物的全面结构信息。对检测条件（包括紫外线照射和响应时间）进行优化，得到了一种改进的比色检测方法，其对NDMA的检测限为0.66 ppm。这种比色检测方案的实际适用性和选择性使其成为开发用于环境水样中NDMA的现场可部署传感器的有希望的候选方法。
