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基于碳量子点的荧光法检测活性药物成分中的亚硝胺杂质

Carbon quantum dot-based fluorometric detection of nitrosamine impurities in active pharmaceutical ingredients.

作者信息

Loganathan Gayathri, Srikanth Pirangi, Shaik Khaja Moinuddin, Nandi Sukhendu

机构信息

Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research S.A.S. Nagar Mohali 160062 Punjab India

出版信息

Nanoscale Adv. 2025 Aug 19. doi: 10.1039/d5na00490j.

DOI:10.1039/d5na00490j
PMID:40919213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12411933/
Abstract

Nitrosamines are genotoxic, mutagenic impurities and are widely encountered in the global landscape of the pharmaceutical industry. There is a need for rapid detection of nitrosamines in a pharmaceutical product. Here, we report the synthesis of carbon quantum dots (CQDs) using a readily available carbon precursor. These CQDs showed attractive fluorescence properties and were employed to fabricate a portable device for the fluorometric detection of nitrosamine impurities in a drug matrix.

摘要

亚硝胺是具有基因毒性、致突变性的杂质，在全球制药行业中广泛存在。需要快速检测药品中的亚硝胺。在此，我们报道了使用一种易得的碳前驱体合成碳量子点（CQDs）。这些碳量子点表现出引人注目的荧光特性，并被用于制造一种便携式装置，用于荧光检测药物基质中的亚硝胺杂质。

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A comprehensive approach for N-nitrosamine determination in pharmaceuticals using a novel HILIC-based solid phase extraction and LC-HRMS.一种使用基于亲水作用色谱的新型固相萃取和液相色谱-高分辨质谱法测定药品中N-亚硝胺的综合方法。
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Colorimetric Detection of Aqueous -Nitrosodimethylamine via Photonitrosation of a Naphtholsulfonate Indicator.
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ACS Sens. 2024 Sep 27;9(9):4655-4661. doi: 10.1021/acssensors.4c00927. Epub 2024 Aug 21.
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Analytical Methodologies to Detect N-Nitrosamine Impurities in Active Pharmaceutical Ingredients, Drug Products and Other Matrices.分析方法检测原料药、药品及其他基质中的 N-亚硝胺杂质
Chem Res Toxicol. 2024 Sep 16;37(9):1456-1483. doi: 10.1021/acs.chemrestox.4c00234. Epub 2024 Aug 19.
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