基于碳量子点的荧光法检测活性药物成分中的亚硝胺杂质
Carbon quantum dot-based fluorometric detection of nitrosamine impurities in active pharmaceutical ingredients.
作者信息
Loganathan Gayathri, Srikanth Pirangi, Shaik Khaja Moinuddin, Nandi Sukhendu
机构信息
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research S.A.S. Nagar Mohali 160062 Punjab India
出版信息
Nanoscale Adv. 2025 Aug 19. doi: 10.1039/d5na00490j.
Nitrosamines are genotoxic, mutagenic impurities and are widely encountered in the global landscape of the pharmaceutical industry. There is a need for rapid detection of nitrosamines in a pharmaceutical product. Here, we report the synthesis of carbon quantum dots (CQDs) using a readily available carbon precursor. These CQDs showed attractive fluorescence properties and were employed to fabricate a portable device for the fluorometric detection of nitrosamine impurities in a drug matrix.
亚硝胺是具有基因毒性、致突变性的杂质，在全球制药行业中广泛存在。需要快速检测药品中的亚硝胺。在此，我们报道了使用一种易得的碳前驱体合成碳量子点（CQDs）。这些碳量子点表现出引人注目的荧光特性，并被用于制造一种便携式装置，用于荧光检测药物基质中的亚硝胺杂质。
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