Beard Jessica C, Swager Timothy M
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
J Org Chem. 2021 Feb 5;86(3):2037-2057. doi: 10.1021/acs.joc.0c02774. Epub 2021 Jan 21.
-Nitrosamines are a class of compounds notorious both for the potent carcinogenicity of many of its members and for their widespread occurrence throughout the human environment, from air and water to our diets and drugs. Considerable effort has been dedicated to understanding -nitrosamines as contaminants, and methods for their prevention, remediation, and detection are ongoing challenges. Understanding the chemistry of -nitrosamines will be key to addressing these challenges. To facilitate such understanding, we focus in this Perspective on the structure, reactivity, and synthetic applications of -nitrosamines with an emphasis on alkyl -nitrosamines. The role of -nitrosamines as water contaminants and the methods for their detection are also discussed.
亚硝胺是一类化合物，因其许多成员具有强大的致癌性以及在人类环境中广泛存在而声名狼藉，从空气、水到我们的饮食和药物。人们已经投入了大量精力来了解亚硝胺作为污染物的情况，其预防、修复和检测方法仍然是持续面临的挑战。了解亚硝胺的化学性质将是应对这些挑战的关键。为了促进这种理解，我们在本综述中重点关注亚硝胺的结构、反应性和合成应用，尤其侧重于烷基亚硝胺。还讨论了亚硝胺作为水污染物的作用及其检测方法。
