Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Dermato-Allergology and Occupational Dermatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Contact Dermatitis. 2024 Nov;91(5):375-378. doi: 10.1111/cod.14678. Epub 2024 Aug 21.
Propolis was added to the European baseline series (EBS) in 2019.
To investigate the frequency and relevance of positive patch tests to propolis in the EBS and to study co-reactivities.
Retrospective study in patients patch tested between June 2019 and November 2023 in a university hospital in Amsterdam, The Netherlands.
Of 3134 consecutive patients, 299 (9.5%) had a positive reaction to propolis 10% pet. Only nine reactions (3%) were judged to be clinically relevant. There were significant co-reactivities to Myroxylon pereirae resin (balsam of Peru), colophonium, fragrance mixes 1 and 2, and to limonene and linalool hydroperoxides. A steep increase in rates of positive reactions to propolis was observed from 2020 to 2023. This was highly likely the result of the replacement of Chinese propolis with Brazilian propolis by the manufacturer.
Positive patch tests for propolis are very frequent in Amsterdam, but only a few of these reactions are relevant. Most are probably (pseudo-)cross-reactions in patients with fragrance allergies. Propolis in the EBS has very limited value for dermatologists and patients in The Netherlands. Changes in patch test materials should be provided to all users to avoid misinterpretation of patch test results.
蜂胶于 2019 年被纳入欧洲基础系列（EBS）。
调查 EBS 中蜂胶斑贴试验阳性的频率和相关性，并研究共同反应性。
这是荷兰阿姆斯特丹一所大学医院在 2019 年 6 月至 2023 年 11 月间进行的一项回顾性研究，对接受斑贴试验的患者进行了研究。
在 3134 例连续患者中，有 299 例（9.5%）对 10%蜂胶 pet 呈阳性反应。只有 9 种反应（3%）被认为具有临床相关性。Myroxylon pereirae resin（秘鲁香脂）、松香、香料混合物 1 和 2 以及柠檬烯和芳樟醇氢过氧化物存在显著的共同反应性。从 2020 年到 2023 年，对蜂胶的阳性反应率急剧上升。这很可能是由于制造商用巴西蜂胶替代了中国蜂胶。
在阿姆斯特丹，对蜂胶的斑贴试验阳性非常常见，但只有少数反应具有相关性。大多数可能是对香料过敏的患者的（假性）交叉反应。EBS 中的蜂胶对荷兰的皮肤科医生和患者几乎没有价值。应向所有使用者提供贴剂材料的变化，以避免对贴剂试验结果的误解。
