Zhang Renjie, Liao Yiling, Yang Xiaoya, Tian Hengyu, Wu Shenfeng, Zeng Qingteng, He Qinghua, Zhang Ruikun, Wei Chunshan, Liu Jialin
Department of General Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Front Surg. 2024 Aug 7;11:1378307. doi: 10.3389/fsurg.2024.1378307. eCollection 2024.
This study aims to explore the analgesic effect of lidocaine administered through the hepatic artery during hepatic artery infusion chemotherapy (HAIC) for hepatocellular carcinoma (HCC).
A total of 45 HCC patients were randomly divided into a study group and a control group. Both groups received oxaliplatin (OXA) based FOLFOX protocol via electronic infusion pump. The study group was continuously infused with 100 mg of lidocaine during HAIC, while 5% glucose solution was infused in the same way as described above. Changes in vital signs, visual analogue score (VAS) and general comfort score (GCQ scale) were recorded before surgery (Time point 0), at the end of infusion (Time point 01), 1 h after HAIC (Time point 02), 3 h after HAIC (Time point 03) and 6 h after HAIC (Time point 04).
At each point of time from Time point 0 through Time point 04, the differences in MAP, RR and SPO between the two groups were not statistically significant ( > 0.05). At each point of time from Time point 01 through Time point 04, the mean VAS scores in the study group were smaller and GCQ scores were higher than those in the control group, and the differences were both statistically significant ( < 0.05).
Lidocaine infusion through the hepatic artery during HAIC effectively reduces intraoperative and postoperative pain and improves patient satisfaction with pain management, making it a valuable technique for clinical practice.
本研究旨在探讨在肝细胞癌（HCC）肝动脉灌注化疗（HAIC）期间经肝动脉给予利多卡因的镇痛效果。
总共45例HCC患者被随机分为研究组和对照组。两组均通过电子输液泵接受基于奥沙利铂（OXA）的FOLFOX方案。研究组在HAIC期间持续输注100mg利多卡因，而以与上述相同的方式输注5%葡萄糖溶液。记录手术前（时间点0）、输注结束时（时间点01）、HAIC后1小时（时间点02）、HAIC后3小时（时间点03）和HAIC后6小时（时间点04）的生命体征、视觉模拟评分（VAS）和总体舒适度评分（GCQ量表）的变化。
从时间点0到时间点04的每个时间点，两组之间的平均动脉压（MAP）、呼吸频率（RR）和血氧饱和度（SPO）差异均无统计学意义（P>0.05）。从时间点01到时间点04的每个时间点，研究组的平均VAS评分低于对照组，GCQ评分高于对照组，差异均有统计学意义（P<0.05）。
HAIC期间经肝动脉输注利多卡因可有效减轻术中和术后疼痛，并提高患者对疼痛管理的满意度，使其成为临床实践中有价值的技术。
