Deng Lu, He Kang, Pan Yixiao, Wang Hai, Luo Yi, Xia Qiang
Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Int J Med Sci. 2021 Mar 15;18(10):2109-2116. doi: 10.7150/ijms.56003. eCollection 2021.
Liver macrophages consist of ontogenically distinct populations termed Kupffer cells and monocyte-derived macrophages. Tumor-associated macrophages (TAMs) inhepatocellularcarcinoma (HCC) play a prominent role in tumormicroenvironment by presenting M1(induced by IFN γ along with LPS) and M2(induced by IL-4 and IL13) polarization. Although TAMs are involved in tumor immune surveillance during the course of HCC, they contribute to tumour progression at different levels by inhibiting the anti-tumor immune response, promoting the generation of blood vessels and lymphatic vessels, and supporting the proliferation and survival of tumor cells. In this paper, the multiple functions of TAMs in HCC were reviewed to provide assistance for future researches about therapeutic approaches.
肝巨噬细胞由在个体发生上不同的群体组成，即库普弗细胞和单核细胞衍生的巨噬细胞。肝细胞癌（HCC）中的肿瘤相关巨噬细胞（TAM）通过呈现M1（由IFNγ和LPS诱导）和M2（由IL-4和IL13诱导）极化，在肿瘤微环境中发挥重要作用。尽管TAM在HCC病程中参与肿瘤免疫监视，但它们通过抑制抗肿瘤免疫反应、促进血管和淋巴管生成以及支持肿瘤细胞的增殖和存活，在不同水平上促进肿瘤进展。本文综述了TAM在HCC中的多种功能，为未来治疗方法的研究提供帮助。
