Özcan Bilge Deniz, Zimmermann Morten Lang, Ren Mingzhe, Bols Mikael
Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 København Ø, Denmark.
Org Biomol Chem. 2024 Sep 11;22(35):7092-7102. doi: 10.1039/d4ob01109k.
While being some of the oldest supramolecular hosts, cyclodextrins remain very popular as molecular binders in materials, devices, artificial enzymes and more. The popularity is undoubtedly connected to the ready availability, carbohydrate biomass origin, biodegradability and water solubility of the cyclodextrins. Many of these applications require synthetic modification of the cyclodextrin - at the simplest the attachment of a linker - but also often attachment of several functional groups, lids, bridges . Here we review state of the art methods of modifying α-cyclodextrin, which include direct modications of unprotected α-cyclodextrin and protection/deprotection method to partially modified cyclodextrins.
作为一些最古老的超分子主体，环糊精作为材料、器件、人工酶等中的分子结合剂仍然非常受欢迎。这种受欢迎程度无疑与环糊精易于获得、源自碳水化合物生物质、可生物降解性和水溶性有关。这些应用中的许多都需要对环糊精进行合成修饰——最简单的是连接子的连接——但通常还需要连接几个官能团、盖子、桥接物等。在这里，我们综述了修饰α-环糊精的现有方法，包括对未保护的α-环糊精的直接修饰以及对部分修饰的环糊精的保护/脱保护方法。
