BRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, Chongqing 400715, P. R. China.
College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, P. R. China.
J Mater Chem B. 2024 Sep 25;12(37):9238-9248. doi: 10.1039/d4tb00237g.
Surface modification of biomedical materials and devices using versatile nanocomposite coatings holds great promise for improving functionalities to defend against life-threatening bacterial infections. In this study, a one-step surface modification strategy was developed to deposit gold nanorods (AuNRs)- and curcumin (CUR)-encapsulated zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (AuNRs-ZIF-CUR NPs or AZC) onto phytic acid (PA)-ε-polylysine (Ply) network coatings. In the solution mixture of PA, Ply and AZC, PA interacted with Ply electrostatic interactions, and can also bind to AZC metal chelation. The as-formed AZC-PA-Ply aggregates could be deposited onto various substrates surface adhesion of PA and gravitational effects. The physicochemical and antibacterial properties of the AZC-PA-Ply network coatings on polydimethylsiloxane (PDMS) substrates were evaluated. The sustained release of zinc ions and CUR, as well as the contact-killing ability of Ply, endowed the AZC-PA-Ply network coatings with good antibacterial chemotherapeutic effects. In addition, the embedded AuNRs in the AZC-PA-Ply network coatings exhibited excellent photothermal conversion efficiency for the ablation of bacteria. Upon near-infrared (NIR) laser irradiation, the AZC-PA-Ply-coated PDMS surfaces exhibited strong antibacterial effects by disrupting the membrane integrity and cellular functions of the adhered bacteria. Thus, the AZC-PA-Ply network coatings displayed combined antibacterial chemotherapeutic and photothermal therapeutic effects. Furthermore, the AZC-PA-Ply-coated PDMS substrates exhibited effective bacterial infection prevention and good biocompatibility in an implant model. Hence, the versatile AZC-PA-Ply network coatings are potentially useful as a multi-modal antibacterial platform to eliminate infectious bacterial pathogens in biomedical applications.
采用多功能纳米复合涂层对生物医学材料和器械进行表面改性，有望提高其功能，以抵御危及生命的细菌感染。在这项研究中，开发了一种一步表面改性策略，将金纳米棒（AuNRs）和姜黄素（CUR）封装的沸石咪唑酯骨架-8（ZIF-8）纳米颗粒（AuNRs-ZIF-CUR NPs 或 AZC）沉积到植酸（PA）-ε-聚赖氨酸（Ply）网络涂层上。在 PA、Ply 和 AZC 的混合溶液中，PA 与 Ply 之间存在静电相互作用，并且还可以与 AZC 发生金属螯合。形成的 AZC-PA-Ply 聚集体可以通过 PA 的表面粘附和重力作用沉积到各种基底上。评估了 PDMS 基底上 AZC-PA-Ply 网络涂层的物理化学和抗菌性能。锌离子和 CUR 的持续释放以及 Ply 的接触杀伤能力赋予了 AZC-PA-Ply 网络涂层良好的抗菌化疗效果。此外，嵌入 AZC-PA-Ply 网络涂层中的 AuNRs 表现出优异的光热转换效率，可用于细菌的消融。在近红外（NIR）激光照射下，AZC-PA-Ply 涂层的 PDMS 表面通过破坏粘附细菌的膜完整性和细胞功能表现出强烈的抗菌作用。因此，AZC-PA-Ply 网络涂层显示出联合抗菌化疗和光热治疗效果。此外，在植入模型中，AZC-PA-Ply 涂层的 PDMS 基底表现出有效的细菌感染预防和良好的生物相容性。因此，多功能 AZC-PA-Ply 网络涂层有望成为一种消除生物医学应用中感染性细菌病原体的多模式抗菌平台。
