Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance, Youjiang Medical University for Nationalities, Baise, China.
Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0095924. doi: 10.1128/aac.00959-24. Epub 2024 Aug 22.
() is closely associated with the diseases such as gastric sinusitis, peptic ulcers, and gastric adenocarcinoma. Its drug resistance is very severe, and new antibiotics are urgently needed. Nine comfrey compounds were screened by antimicrobial susceptibility testing, among which deoxyshikonin had the best inhibitory effect, with a minimum inhibitory concentration (MIC) of 0.5-1 µg/mL. In addition, deoxyshikonin also has a good antibacterial effect in an acidic environment, it is highly safe, and does not readily develop drug resistance. Through experiments, it was proven that deoxyshikonin (7 mg/kg) had a beneficial therapeutic effect on acute gastritis in mice infected with the multidrug-resistant BS001 strain. After treatment with desoxyshikonin, colonization of in the gastric mucosa of mice was significantly reduced, gastric mucosal damage was repaired, inflammatory factors were reduced, and the treatment effect was better than that of standard triple therapy. Therefore, deoxyshikonin is a promising lead drug to solve the difficulty of drug resistance in , and its antibacterial mechanism may be to destroy the biofilm and cause an oxidation reaction.
（）与胃窦炎、消化性溃疡和胃腺癌等疾病密切相关。其耐药性非常严重，急需新的抗生素。通过抗菌药敏试验筛选了 9 种瑞香素化合物，其中去氧鬼臼毒素的抑制效果最好，最小抑菌浓度（MIC）为 0.5-1μg/ml。此外，去氧鬼臼毒素在酸性环境中也具有良好的抗菌作用，安全性高，不易产生耐药性。实验证明，去氧鬼臼毒素（7mg/kg）对感染多药耐药 BS001 株的小鼠急性胃炎具有有益的治疗作用。用去氧鬼臼毒素治疗后，小鼠胃黏膜中的定植明显减少，胃黏膜损伤得到修复，炎症因子减少，治疗效果优于标准三联疗法。因此，去氧鬼臼毒素是一种很有前途的解决耐多药问题的先导药物，其抗菌机制可能是破坏生物膜并引起氧化反应。
