Orsatti Fábio Lera, de Queiroz Freitas Augusto Corrêa, Borges Anna Victória Bernardes E, Santato Alexia Souza, de Oliveira Assumpção Claudio, Souza Markus Vinicius Campos, da Silva Marcos Vinicius, Orsatti Cláudio Lera
Exercise Biology Laboratory (BioEx), Department of Sport Science, Health Science Institute, Federal University of Triangulo Mineiro (UFTM), Av. Frei Paulino, 30, Uberaba, MG, 38025-180, Brazil.
Department of Microbiology, Immunology, And Parasitology, Institute of Biological and Natural Sciences of Federal University of Triangulo Mineiro, Uberaba, MG, 38025-350, Brazil.
Mol Cell Biochem. 2025 Mar;480(3):1381-1401. doi: 10.1007/s11010-024-05089-8. Epub 2024 Aug 22.
Cardiovascular disease is one of the leading causes of mortality worldwide, primarily driven by atherosclerosis, a chronic inflammatory condition contributing significantly to fatalities. Various biological determinants affecting cardiovascular health across different age and sex groups have been identified. In this context, recent attention has focused on the potential therapeutic and preventive role of increasing circulating levels of heat shock protein 27 (plasma HSP27) in combating atherosclerosis. Plasma HSP27 is recognized for its protective function in inflammatory atherogenesis, offering promising avenues for intervention and management strategies against this prevalent cardiovascular ailment. Exercise has emerged as a pivotal strategy in preventing and managing cardiovascular disease, with literature indicating an increase in plasma HSP27 levels post-exercise. However, there is limited understanding of the impact of exercise on the release of HSP27 into circulation. Clarifying these aspects is crucial for understanding the role of exercise in modulating plasma HSP27 levels and its potential implications for cardiovascular health across diverse populations. Therefore, this review aims to establish a more comprehensive understanding of the relationship between plasma HSP27 and exercise.
心血管疾病是全球主要死因之一，主要由动脉粥样硬化引发，这是一种慢性炎症性疾病，对死亡率有重大影响。已确定了影响不同年龄和性别群体心血管健康的各种生物学决定因素。在此背景下，最近的关注焦点在于提高循环热休克蛋白27（血浆HSP27）水平在对抗动脉粥样硬化中的潜在治疗和预防作用。血浆HSP27因其在炎症性动脉粥样硬化形成中的保护功能而受到认可，为针对这种普遍的心血管疾病的干预和管理策略提供了有前景的途径。运动已成为预防和管理心血管疾病的关键策略，文献表明运动后血浆HSP27水平会升高。然而，对于运动对HSP27释放到循环中的影响了解有限。阐明这些方面对于理解运动在调节血浆HSP27水平中的作用及其对不同人群心血管健康的潜在影响至关重要。因此，本综述旨在更全面地理解血浆HSP27与运动之间的关系。
