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[关于两例无明显神经功能障碍的全身性李斯特菌病病例]

[On two cases of systemic listeriosis without dominant neurological compromise].

作者信息

Taborro Andrés, Iwanow Pablo, Antunes Lucía, Sandoval Guggia Micaela, Montaldi Micaela, Gill Daniela, Rossi Paola G, Teglia Osvaldo F

机构信息

Servicio de Infectología, Policlínico PAMI I, Rosario, Santa Fe, Argentina. E-mail:

Servicio de Infectología, Policlínico PAMI I, Rosario, Santa Fe, Argentina.

出版信息

Medicina (B Aires). 2024;84(4):746-749.

Abstract

Listeria monocytogenes is a Gram-positive aerobic bacterium; found ubiquitously in nature; which mainly affects newborns, older adults, immunosuppressed patients and pregnant women. However, Listeria disease can occur in the healthy population. Invasive listeriosis has three dominant clinical forms, bacteremia, neurolisteriosis and maternal-neonatal infection. Localized forms are infrequently described. The disease occurs mainly secondary to the consumption of contaminated food, including unpasteurized milk or cheese, and occurs in the form of isolated cases or outbreaks, usually beginning a few days after consumption of the contaminated food; although it has been described up to 2 months after ingesting them. There is also the possibility of direct transmission from animals and vertical transmission. Systemic listeriosis without dominant neurological symptoms is a rare event. Two cases are presented. The first was spondylodiscitis in a normal host and the second was Listeria bacteremia in a febrile immunocompromised patient.

摘要

单核细胞增生李斯特菌是一种革兰氏阳性需氧菌;在自然界中广泛存在;主要影响新生儿、老年人、免疫抑制患者和孕妇。然而,李斯特菌病也可发生在健康人群中。侵袭性李斯特菌病有三种主要临床形式,即菌血症、神经李斯特菌病和母婴感染。局部形式的报道较少。该疾病主要继发于食用受污染的食物,包括未巴氏杀菌的牛奶或奶酪,以散发病例或暴发形式出现,通常在食用受污染食物几天后发病;尽管也有在摄入受污染食物后长达2个月才发病的报道。也存在动物直接传播和垂直传播的可能性。无明显神经症状的全身性李斯特菌病是罕见事件。本文介绍了两例病例。第一例是一名正常宿主发生的脊椎椎间盘炎,第二例是一名发热免疫功能低下患者发生的李斯特菌菌血症。

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