Cohen M M, Yeung R, Kilam S, Wang H R
Department of Surgery, University of Toronto, Ontario, Canada.
Dig Dis Sci. 1988 May;33(5):513-7. doi: 10.1007/BF01798349.
Mild irritants have been shown to protect the rat gastric mucosa against noxious agents. This study was designed to test the protective potential of low-dose ethanol against acetylsalicylic acid (ASA) -induced gastric injury. Ten healthy volunteers who were nondrinkers and had normal baseline upper gastrointestinal endoscopy participated in a randomized double-blind crossover study. Thirty minutes after either vodka (37.5 ml) in tomato juice or tomato juice alone, each subject took 975 mg ASA and then underwent endoscopy 1 hr later. The degree of mucosal injury was scored, and blood was taken for ethanol and salicylate levels. There was a washout interval of seven days between the two treatments. Endoscopic scores were analyzed using the sign test. After a single dose of ASA, mucosal injury was confined to the fundus and antrum, while the duodenum was minimally affected. A significant reduction in antral damage was seen with ethanol pretreatment (P less than 0.05). The same trend was evident in the fundus but did not achieve statistical significance. Serum salicylate levels averaged 13.2 +/- 0.8 mg/100 ml and were not different between the two treatments. Ethanol concentration ranged from 1.1 to 6.2 mmol/liter following the vodka drink and was 0 after the placebo.
轻度刺激物已被证明可保护大鼠胃黏膜免受有害物质的侵害。本研究旨在测试低剂量乙醇对乙酰水杨酸（ASA）诱导的胃损伤的保护潜力。10名不饮酒且基线时上消化道内镜检查正常的健康志愿者参与了一项随机双盲交叉研究。在饮用番茄汁中的伏特加（37.5毫升）或仅饮用番茄汁30分钟后，每位受试者服用975毫克ASA，然后在1小时后接受内镜检查。对黏膜损伤程度进行评分，并采集血液检测乙醇和水杨酸盐水平。两种治疗之间有7天的洗脱期。使用符号检验分析内镜评分。单剂量ASA后，黏膜损伤局限于胃底和胃窦，而十二指肠受影响最小。乙醇预处理后胃窦损伤明显减轻（P小于0.05）。胃底也有同样的趋势，但未达到统计学意义。两种治疗的血清水杨酸盐水平平均为13.2±0.8毫克/100毫升，无差异。饮用伏特加后乙醇浓度范围为1.1至6.2毫摩尔/升，安慰剂组后为0。
