Department of Psychiatry, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China.
Department of Psychiatry, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China.
PLoS One. 2024 Aug 22;19(8):e0307428. doi: 10.1371/journal.pone.0307428. eCollection 2024.
Previous studies evaluating the association between prediabetes and depression have shown inconsistent results. Consequently, the aim of the systematic review and meta-analysis was to investigate whether prediabetes is associated with depression in the general population.
Relevant observational studies were obtained by searching the Medline, Web of Science, and Embase databases. A random-effects model was utilized to pool the results by incorporating the influence of heterogeneity. Multiple subgroup analysis was performed to evaluate the influence of the study characteristics on the outcome.
Sixteen large-scale cross-sectional studies involving 322,863 participants were included. Among the total participants, 82,154 (25.4%) had prediabetes. The pooled results showed that prediabetes was associated with a higher prevalence of depression in this population (odds ratio [OR]: 1.16, 95% confidence interval [CI]: 1.05 to 1.28, p = 0.003; I2 = 58%). Subgroup analysis showed a stronger association between prediabetes and depression in younger subjects (<50 years old, OR: 1.25, 95% CI: 1.04 to 1.50) than that in older subjects (≥50 years old, OR: 1.05, 95% CI: 1.10 to 1.10; p for subgroup difference = 0.03). Other study characteristics, such as the study country, sex of the participants, definition of prediabetes, methods for the detection of depression, and study quality score, did not seem to significantly affect the results (p for subgroup difference all > 0.05).
Prediabetes may be associated with a slightly higher prevalence of depression in the general population, particularly in subjects aged <50 years old.
先前评估糖尿病前期与抑郁之间关联的研究结果并不一致。因此，本系统评价和荟萃分析旨在调查一般人群中糖尿病前期是否与抑郁相关。
通过检索 Medline、Web of Science 和 Embase 数据库获得相关观察性研究。采用随机效应模型纳入异质性影响，对结果进行合并。进行了多项亚组分析，以评估研究特征对结果的影响。
纳入了 16 项涉及 322863 名参与者的大型横断面研究。在所有参与者中，82154 人（25.4%）患有糖尿病前期。汇总结果表明，糖尿病前期与该人群中更高的抑郁发生率相关（比值比 [OR]：1.16，95%置信区间 [CI]：1.05 至 1.28，p = 0.003；I2 = 58%）。亚组分析显示，在较年轻的受试者（<50 岁，OR：1.25，95%CI：1.04 至 1.50）中，糖尿病前期与抑郁之间的关联强于较年长的受试者（≥50 岁，OR：1.05，95%CI：1.10 至 1.10；p 亚组差异=0.03）。其他研究特征，如研究国家、参与者的性别、糖尿病前期的定义、抑郁检测方法和研究质量评分，似乎并未显著影响结果（p 亚组差异均>0.05）。
糖尿病前期可能与一般人群中略高的抑郁发生率相关，特别是在年龄<50 岁的人群中。
