马来西亚 2 型糖尿病和糖尿病前期的患病率：系统评价和荟萃分析。
Prevalence of type-2 diabetes and prediabetes in Malaysia: A systematic review and meta-analysis.
机构信息
Department of Mathematics and Statistics, The University of Haripur, Haripur, Khyber Pakhtunkhwa, Pakistan.
Department of Statistics, GC University Lahore, Lahore, Pakistan.
出版信息
PLoS One. 2022 Jan 27;17(1):e0263139. doi: 10.1371/journal.pone.0263139. eCollection 2022.
OBJECTIVE
The main purpose of this study was to investigate the pooled prevalence of prediabetes and type-2 diabetes in the general population of Malaysia.
METHOD
We systematically searched Medline (PubMed), Embase, Web of Science, Google Scholar and Malaysian Journals Online to identify relevant studies published between January 1, 1995, and November 30, 2021, on the prevalence of type-2 diabetes in Malaysia. Random-effects meta-analyses were used to obtain the pooled prevalence of diabetes and prediabetes. Subgroup analyses also used to analyze to the potential sources of heterogeneity. Meta- regression was carried to assess associations between study characteristics and diabetes prevalence. Three independent authors selected studies and conducted the quality assessment. The quality of the final evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
RESULTS
Of 2689 potentially relevant studies, 786 titles and abstract were screened. Fifteen studies with 103063 individuals were eligible to be included in the meta-analyses. The pooled prevalence of diabetes was 14.39% (95% CI, 12.51%-16.38%; I2 = 98.4%, 103063 participants from 15 studies). The pooled prevalence of prediabetes was 11.62% (95% CI, 7.17%-16.97%; I2 = 99.8, 88702 participants from 9 studies). The subgroup analysis showed statistically significant differences in diabetes prevalence by the ethical sub-populations with highest in Indians (25.10%; 95% CI, 20.19%-30.35%), followed by Malays (15.25%; 95% CI, 11.59%-19.29%), Chinese (12.87%; 95% CI, 9.73%-16.37%), Bumiputeras (8.62%; 95% CI, 5.41%-12.47%) and others (6.91%; 95% CI, 5.71%-8.19%). There was no evidence of publication bias, although heterogeneity was high (I2 ranged from 0.00% to 99·8%). The quality of evidence based on GRADE was low.
CONCLUSIONS
Results of this study suggest that a high prevalence of prediabetes and diabetes in Malaysia. The diabetes prevalence is associated with time period and increasing age. The Malaysian government should develop a comprehensive approach and strategy to enhance diabetes awareness, control, prevention, and treatment.
TRIAL REGISTRATION
Trial registration no. PROSPERO CRD42021255894; https://clinicaltrials.gov/.
目的
本研究的主要目的是调查马来西亚普通人群中糖尿病前期和 2 型糖尿病的总患病率。
方法
我们系统地检索了 Medline（PubMed）、Embase、Web of Science、Google Scholar 和马来西亚在线期刊，以确定 1995 年 1 月 1 日至 2021 年 11 月 30 日期间发表的关于马来西亚 2 型糖尿病患病率的相关研究。采用随机效应荟萃分析获得糖尿病和糖尿病前期的汇总患病率。还进行了亚组分析，以分析潜在的异质性来源。采用荟萃回归评估研究特征与糖尿病患病率之间的关联。三名独立作者选择研究并进行质量评估。使用推荐评估、制定与评估分级（GRADE）方法评估最终证据的质量。
结果
在 2689 篇潜在相关研究中，筛选了 786 篇标题和摘要。15 项研究纳入了 103063 名参与者进行荟萃分析。糖尿病的总患病率为 14.39%（95%CI，12.51%-16.38%；I2=98.4%，15 项研究的 103063 名参与者）。糖尿病前期的总患病率为 11.62%（95%CI，7.17%-16.97%；I2=99.8，9 项研究的 88702 名参与者）。亚组分析显示，按道德亚人群划分的糖尿病患病率存在统计学差异，印度人最高（25.10%；95%CI，20.19%-30.35%），其次是马来人（15.25%；95%CI，11.59%-19.29%）、华人（12.87%；95%CI，9.73%-16.37%）、Bumiputeras（8.62%；95%CI，5.41%-12.47%）和其他人（6.91%；95%CI，5.71%-8.19%）。虽然存在高度异质性（I2 范围为 0.00%-99·8%），但没有证据表明存在发表偏倚。基于 GRADE 的证据质量为低。
结论
本研究结果表明，马来西亚糖尿病前期和糖尿病的患病率较高。糖尿病的患病率与时间和年龄增长有关。马来西亚政府应制定全面的方法和策略，以提高对糖尿病的认识、控制、预防和治疗水平。
试验注册
临床试验编号 PROSPERO CRD42021255894；https://clinicaltrials.gov/。
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