临床试验设计与解读中的当前问题。
Current issues in the design and interpretation of clinical trials.
作者信息
Pocock S J
出版信息
Br Med J (Clin Res Ed). 1985 Jan 5;290(6461):39-42. doi: 10.1136/bmj.290.6461.39.
Abstract
Though there have been considerable improvements in the use of statistical methods for clinical trials in recent years, there remain major practical difficulties in the design and interpretation of many trials. This paper concentrates on problems relating to randomisation, the overemphasis on significance testing, and the inadequate size of many trials. Each topic is illustrated by examples from recent trials.
摘要
尽管近年来在临床试验统计方法的应用方面有了相当大的改进，但在许多试验的设计和解释方面仍然存在重大的实际困难。本文着重探讨与随机化、对显著性检验的过度强调以及许多试验规模不足相关的问题。每个主题都通过近期试验中的实例进行说明。
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