Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
Department of Pharmaceutics, College of Pharmacy, Northern Border University, Rafha 91911, Saudi Arabia.
Pathol Res Pract. 2024 Oct;262:155549. doi: 10.1016/j.prp.2024.155549. Epub 2024 Aug 14.
Long non-coding RNAs (lncRNAs) significantly influence gene regulation across epigenetic, transcriptional, and post-transcriptional levels through their interactions with DNA, RNA, and proteins. There is growing evidence of lncRNAs' critical roles in the emergence and progression of various diseases, including urological tumors (UTs), such as cancers of the kidney, bladder, and prostate. Research increasingly links lncRNA dysregulation to diverse cellular processes like invasion, metastasis, apoptosis, and chromatin remodeling. Among these, HOTAIR stands out for its pivotal role in oncogenesis, impacting treatment resistance, cell migration, proliferation, survival, and genomic integrity. This review provides an overview of HOTAIR's functions, its identification, and its biological significance. Furthermore, it delves into HOTAIR's involvement in UTs, underlining its potential as a therapeutic target and biomarker for innovative approaches to treating these cancers.
长非编码 RNA（lncRNA）通过与 DNA、RNA 和蛋白质的相互作用，在表观遗传、转录和转录后水平上显著影响基因调控。越来越多的证据表明，lncRNA 在各种疾病（包括泌尿系统肿瘤[UTs]，如肾脏、膀胱和前列腺癌）的发生和进展中起着关键作用。研究越来越多地将 lncRNA 失调与多种细胞过程联系起来，如侵袭、转移、凋亡和染色质重塑。在这些过程中，HOTAIR 因其在致癌作用中的关键作用而引人注目，影响治疗耐药性、细胞迁移、增殖、存活和基因组完整性。本综述概述了 HOTAIR 的功能、鉴定及其生物学意义。此外，还深入探讨了 HOTAIR 在 UTs 中的作用，强调了其作为治疗这些癌症的创新方法的治疗靶点和生物标志物的潜力。
