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导致正常压力脑积水的前庭神经鞘瘤。

Vestibular schwannoma causing normal pressure hydrocephalus.

作者信息

Hayes Alexander, Wilson Mark, Gontsarova Anastassia, Carswell Christopher

机构信息

Imperial College London, Department of Brain Sciences, London, UK

Neurosurgery, Imperial College Healthcare NHS Trust, London, UK.

出版信息

Pract Neurol. 2025 Jan 16;25(1):70-74. doi: 10.1136/pn-2024-004240.

Abstract

Vestibular schwannoma is a common benign tumour that may cause local complications. However, vestibular schwannoma has a known association with communicating hydrocephalus presenting with symptoms of normal pressure hydrocephalus and requiring treatment by ventricular shunting or tumour resection. We report a 79-year-old woman who presented with subacute gait apraxia, cognitive impairment and urinary incontinence. CT and MR imaging identified a 20 mm vestibular schwannoma and communicating hydrocephalus; her cerebrospinal fluid (CSF) protein was elevated. Her symptoms improved following ventriculoperitoneal shunt insertion. The mechanism by which non-obstructing vestibular schwannoma causes hydrocephalus is unclear, but hyperproteinorrachia is probably important, likely by impeding CSF resorption.

摘要

前庭神经鞘瘤是一种常见的良性肿瘤,可能会引起局部并发症。然而,前庭神经鞘瘤与交通性脑积水有关,可表现为正常压力脑积水的症状,需要通过脑室分流或肿瘤切除进行治疗。我们报告一名79岁女性,她出现亚急性步态失用、认知障碍和尿失禁。CT和磁共振成像显示有一个20毫米的前庭神经鞘瘤和交通性脑积水;她的脑脊液蛋白升高。在插入脑室腹腔分流管后,她的症状有所改善。非阻塞性前庭神经鞘瘤导致脑积水的机制尚不清楚,但高蛋白脑脊液可能很重要,可能是通过阻碍脑脊液吸收起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3745/11877107/476b874bd35f/pn-25-1-g001.jpg

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