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大型前庭神经鞘瘤相关脑积水的管理

Management of hydrocephalus associated with large vestibular schwannomas.

作者信息

Lemnos Leslie, Troude Lucas, Boucekine Mohamed, Gargula Stéphane, Balossier Anne, Régis Jean, Roche Pierre-Hugues

机构信息

Department of Neurosurgery, North University Hospital, APHM-AMU Chemin des Bourrely, 13015 Marseille, France.

Department of statistical analysis, University of medical and paramedical sciences, Aix-Marseille University (AMU), 27 boulevard Jean Moulin, 13385 Marseille, France.

出版信息

Brain Spine. 2025 Jul 3;5:104318. doi: 10.1016/j.bas.2025.104318. eCollection 2025.

Abstract

INTRODUCTION

Some patients with vestibular schwannoma (VS) may present with hydrocephalus.

RESEARCH QUESTION

In such cases, some authors suggest cerebrospinal fluid (CSF) shunting, while others prefer tumor removal from the outset.

MATERIAL AND METHODS

In our study, we retrospectively compared patients for whom we chose to treat the hydrocephalus with CSF shunting and those for whom VS surgery was performed first.

RESULTS

Among a group of n consecutive patients harboring a stage 3 and 4 VS and eligible for resection, 34 patients presented with hydrocephalus. Thirteen patients underwent CSF shunting (group 1). Twenty-one patients had their VS removed first (group 2). Among the latter group, 18 patients had resolution of hydrocephalus. There was a significant difference between group 1 and 2 in the presence of signs of intracranial hypertension (p = 0.00), preoperative tumor volume (p = 0.04).Previous radiosurgery and a strong adherence of the tumor capsule to the brain were statistically associated with requirement of CSF shunting (p = 0.01).

DISCUSSION AND CONCLUSION

The results of this study suggest that VS patients presenting with a well-tolerated hydrocephalus should be preferentially treated of their schwannoma with rare need for a shunt.

摘要

引言

一些前庭神经鞘瘤(VS)患者可能会出现脑积水。

研究问题

在这种情况下,一些作者建议进行脑脊液(CSF)分流,而另一些作者则倾向于从一开始就切除肿瘤。

材料与方法

在我们的研究中,我们回顾性地比较了选择通过脑脊液分流治疗脑积水的患者和首先进行VS手术的患者。

结果

在一组连续的n例患有3期和4期VS且适合切除的患者中,34例出现脑积水。13例患者接受了脑脊液分流(第1组)。21例患者首先切除了VS(第2组)。在后一组中,18例患者的脑积水得到缓解。第1组和第2组在颅内高压体征(p = 0.00)、术前肿瘤体积(p = 0.04)方面存在显著差异。既往接受过放射外科治疗以及肿瘤包膜与脑紧密粘连与脑脊液分流的需求在统计学上相关(p = 0.01)。

讨论与结论

本研究结果表明,对于脑积水耐受性良好的VS患者,应优先治疗其神经鞘瘤,很少需要进行分流。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f6/12274939/28aff82e8bbc/gr1.jpg

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