• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

运动前补充酮单酯和高剂量葡萄糖与单独补充葡萄糖相比，并不影响运动后即刻的促红细胞生成素浓度。

Ketone monoester plus high-dose glucose supplementation before exercise does not affect immediate post-exercise erythropoietin concentrations versus glucose alone.

机构信息

Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine (USARIEM), Natick, Massachusetts, USA.

Oak Ridge Institute for Science and Education, Belcamp, Maryland, USA.

出版信息

Physiol Rep. 2024 Aug;12(16):e70009. doi: 10.14814/phy2.70009.

DOI:10.14814/phy2.70009
PMID:39174870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11341272/
Abstract

The objective of this study was to examine the effect of consuming ketone monoester plus a high dose of carbohydrate from glucose (KE + CHO) on the change in erythropoietin (EPO) concentrations during load carriage exercise compared with carbohydrate (CHO) alone. Using a randomized, crossover design, 12 males consumed KE + CHO (573 mg KE/kg body mass, 110 g glucose) or CHO (110 g glucose) 30 min before 4 miles of self-paced treadmill exercise (KE + CHO:51 ± 13%, CHO: 52 ± 12% V̇O) wearing a weighted vest (30% body mass; 25 ± 3 kg). Blood samples for analysis were obtained under resting fasted conditions before (Baseline) consuming the KE + CHO or CHO supplement and immediately after exercise (Post). βHB increased (p < 0.05) from Baseline to Post in KE + CHO, with no change in CHO. Glucose and glycerol increased (p < 0.05) from Baseline to Post in CHO, with no effect of time in KE + CHO. Insulin and lactate increased (p < 0.05) from Baseline to Post independent of treatment. EPO increased (p < 0.05) from Baseline to Post in KE + CHO and CHO with no difference between treatments. Although KE + CHO altered βHB, glucose, and glycerol concentrations, results from this study suggest that KE + CHO supplementation before load carriage exercise does not enhance immediate post-exercise increases in EPO compared with CHO alone.

摘要

本研究旨在考察在负荷携带运动中摄入酮单酯加高剂量葡萄糖碳水化合物（KE+CHO）与单独摄入碳水化合物（CHO）相比对促红细胞生成素（EPO）浓度变化的影响。采用随机交叉设计，12 名男性在 4 英里自行调节跑步机运动（KE+CHO：51±13%，CHO：52±12% V̇O）前 30 分钟内分别摄入 KE+CHO（573mg KE/kg 体重，110g 葡萄糖）或 CHO（110g 葡萄糖），并穿着加重背心（30%体重；25±3kg）。在摄入 KE+CHO 或 CHO 补充剂之前（基础）和运动后立即（后），在禁食休息状态下采集血液样本进行分析。KE+CHO 中的 βHB 从基础到后增加（p<0.05），CHO 中没有变化。CHO 中的葡萄糖和甘油从基础到后增加（p<0.05），KE+CHO 中没有时间的影响。胰岛素和乳酸从基础到后增加（p<0.05），与治疗无关。KE+CHO 和 CHO 中的 EPO 从基础到后增加（p<0.05），两种处理之间没有差异。尽管 KE+CHO 改变了 βHB、葡萄糖和甘油浓度，但本研究结果表明，与单独摄入 CHO 相比，在负荷携带运动前补充 KE+CHO 并不能增强运动后即刻 EPO 的增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb09/11341272/0529c87ea825/PHY2-12-e70009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb09/11341272/81c83f4995a1/PHY2-12-e70009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb09/11341272/7aee28e39278/PHY2-12-e70009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb09/11341272/0529c87ea825/PHY2-12-e70009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb09/11341272/81c83f4995a1/PHY2-12-e70009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb09/11341272/7aee28e39278/PHY2-12-e70009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb09/11341272/0529c87ea825/PHY2-12-e70009-g003.jpg

相似文献

1
Ketone monoester plus high-dose glucose supplementation before exercise does not affect immediate post-exercise erythropoietin concentrations versus glucose alone.运动前补充酮单酯和高剂量葡萄糖与单独补充葡萄糖相比，并不影响运动后即刻的促红细胞生成素浓度。
Physiol Rep. 2024 Aug;12(16):e70009. doi: 10.14814/phy2.70009.
2
Ketone Monoester Plus Carbohydrate Supplementation Does Not Alter Exogenous and Plasma Glucose Oxidation or Metabolic Clearance Rate During Exercise in Men Compared with Carbohydrate Alone.酮酯单加碳水化合物补充与单独碳水化合物相比，不会改变男性运动中外源和血浆葡萄糖氧化或代谢清除率。
J Nutr. 2023 Jun;153(6):1696-1709. doi: 10.1016/j.tjnut.2023.03.002. Epub 2023 Mar 8.
3
No Benefit of Ingestion of a Ketone Monoester Supplement on 10-km Running Performance.酮单酯补剂摄入对 10 公里跑成绩无益。
Med Sci Sports Exerc. 2019 Dec;51(12):2506-2515. doi: 10.1249/MSS.0000000000002065.
4
Acute Ingestion of a Ketone Monoester without Co-ingestion of Carbohydrate Improves Running Economy in Male Endurance Runners.急性摄入酮单酯而不同时摄入碳水化合物可改善男性耐力跑运动员的跑步经济性。
Med Sci Sports Exerc. 2024 Jan 1;56(1):134-142. doi: 10.1249/MSS.0000000000003278. Epub 2023 Aug 11.
5
Exogenous Ketosis Impairs 30-min Time-Trial Performance Independent of Bicarbonate Supplementation.外源性酮症会损害30分钟计时赛成绩，且与碳酸氢盐补充无关。
Med Sci Sports Exerc. 2021 May 1;53(5):1068-1078. doi: 10.1249/MSS.0000000000002552.
6
Effects of acute nutritional ketosis during exercise in adults with glycogen storage disease type IIIa are phenotype-specific: An investigator-initiated, randomized, crossover study.运动中急性营养性酮症对 IIIa 型糖原贮积病成人的影响具有表型特异性：一项由研究者发起的、随机、交叉研究。
J Inherit Metab Dis. 2021 Jan;44(1):226-239. doi: 10.1002/jimd.12302. Epub 2020 Sep 7.
7
The effect of 1,3-butanediol and carbohydrate supplementation on running performance.1,3-丁二醇和碳水化合物补充对跑步表现的影响。
J Sci Med Sport. 2019 Jun;22(6):702-706. doi: 10.1016/j.jsams.2018.11.027. Epub 2018 Dec 6.
8
A ketone monoester drink reduces the glycemic response to an oral glucose challenge in individuals with obesity: a randomized trial.酮单酯饮料可降低肥胖个体口服葡萄糖挑战后的血糖反应：一项随机试验。
Am J Clin Nutr. 2019 Dec 1;110(6):1491-1501. doi: 10.1093/ajcn/nqz232.
9
Intermittent Running and Cognitive Performance after Ketone Ester Ingestion.间歇性跑步和酮酯摄入后的认知表现。
Med Sci Sports Exerc. 2018 Nov;50(11):2330-2338. doi: 10.1249/MSS.0000000000001700.
10
Bicarbonate Unlocks the Ergogenic Action of Ketone Monoester Intake in Endurance Exercise.碳酸氢盐能使酮单酯在耐力运动中的促效作用释放出来。
Med Sci Sports Exerc. 2021 Feb 1;53(2):431-441. doi: 10.1249/MSS.0000000000002467.

本文引用的文献

1
A very-low-calorie ketogenic diet normalises obesity-related enhanced levels of erythropoietin compared with a low-calorie diet or bariatric surgery.极低卡路里生酮饮食与低卡路里饮食或减重手术相比，可使肥胖相关的促红细胞生成素水平恢复正常。
J Endocrinol Invest. 2024 Nov;47(11):2701-2713. doi: 10.1007/s40618-024-02364-9. Epub 2024 May 2.
2
Exogenous ketosis elevates circulating erythropoietin and stimulates muscular angiogenesis during endurance training overload.外源性酮症在耐力训练超负荷期间升高循环红细胞生成素并刺激肌肉血管生成。
J Physiol. 2023 Jun;601(12):2345-2358. doi: 10.1113/JP284346. Epub 2023 Apr 27.
3
Ketone Monoester Plus Carbohydrate Supplementation Does Not Alter Exogenous and Plasma Glucose Oxidation or Metabolic Clearance Rate During Exercise in Men Compared with Carbohydrate Alone.
酮酯单加碳水化合物补充与单独碳水化合物相比，不会改变男性运动中外源和血浆葡萄糖氧化或代谢清除率。
J Nutr. 2023 Jun;153(6):1696-1709. doi: 10.1016/j.tjnut.2023.03.002. Epub 2023 Mar 8.
4
Ketone monoester ingestion increases postexercise serum erythropoietin concentrations in healthy men.酮单酯摄入可增加健康男性运动后血清促红细胞生成素浓度。
Am J Physiol Endocrinol Metab. 2023 Jan 1;324(1):E56-E61. doi: 10.1152/ajpendo.00264.2022. Epub 2022 Nov 30.
5
Effects of Exogenous Ketone Supplementation on Blood Glucose: A Systematic Review and Meta-analysis.外源性酮补充对血糖的影响：系统评价和荟萃分析。
Adv Nutr. 2022 Oct 2;13(5):1697-1714. doi: 10.1093/advances/nmac036.
6
Energy deficit increases hepcidin and exacerbates declines in dietary iron absorption following strenuous physical activity: a randomized-controlled cross-over trial.剧烈运动后能量亏空会增加铁调素并加剧膳食铁吸收的下降：一项随机对照交叉试验。
Am J Clin Nutr. 2021 Feb 2;113(2):359-369. doi: 10.1093/ajcn/nqaa289.
7
Exogenous ketosis impacts neither performance nor muscle glycogen breakdown in prolonged endurance exercise.外源性酮症对长时间耐力运动中的运动表现和肌肉糖原分解均无影响。
J Appl Physiol (1985). 2020 Jun 1;128(6):1643-1653. doi: 10.1152/japplphysiol.00092.2020. Epub 2020 May 14.
8
Utility of Ketone Supplementation to Enhance Physical Performance: A Systematic Review.酮补充剂在提高身体表现方面的效用：系统评价。
Adv Nutr. 2020 Mar 1;11(2):412-419. doi: 10.1093/advances/nmz104.
9
Exercising with low muscle glycogen content increases fat oxidation and decreases endogenous, but not exogenous carbohydrate oxidation.在肌肉糖原含量较低的情况下进行运动，会增加脂肪氧化，减少内源性（而非外源性）碳水化合物氧化。
Metabolism. 2019 Aug;97:1-8. doi: 10.1016/j.metabol.2019.05.003. Epub 2019 May 13.
10
Role of ketone signaling in the hepatic response to fasting.酮体信号在肝脏对禁食反应中的作用。
Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G623-G631. doi: 10.1152/ajpgi.00415.2017. Epub 2019 Feb 15.