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探讨室内/室外时间差异和氡暴露作为导致非吸烟女性肺癌风险意外增加的可能因素。

Exploring the Disparity in Indoor/Outdoor Time and Radon Exposure as Possible Factors Contributing to the Unexpected Increase in Lung Cancer Risk among Non-Smoking Women.

作者信息

Safari Arash, Mortazavi Seyed Alireza, Ghadimi-Moghadam Abdolkarim, Haghani Masoud, Mortazavi Seyed Mohammad Javad, Sihver Lembit

机构信息

Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

MVLS College, The University of Glasgow, Glasgow, Scotland, UK.

出版信息

J Biomed Phys Eng. 2024 Aug 1;14(4):415-420. doi: 10.31661/jbpe.v0i0.2312-1701. eCollection 2024 Aug.

Abstract

According to a NIH study, Lung cancer among individuals who have never smoked is more prevalent in women and occurs at an earlier age than in smokers. The rise in lung cancer rates among female non-smokers might be linked to radon inhalation and should be further investigated. Our theory is based on the differences in radon exposure between males and females, which can be attributed to the variations in time spent indoors versus outdoors. Over the past few years, the smoking rates have shown a steady decline in the United States and other developed countries. This decrease in smoking prevalence has led to a new shift in the primary risk factors associated with lung cancer. Although tobacco smoke historically served as the primary cause of lung cancer, the reduction in smoking rates has allowed other risk factors, such as radon exposure, to come to the forefront. Given that women in certain countries, on average, might spend more time indoors compared to men, they are potentially exposed to higher levels of radon. This increased exposure could explain the rising rates of lung cancer among female non-smokers. The theory is still in its nascent stages and requires further research and validation. However, if proven correct, it could significantly alter our understanding of lung cancer risk factors and lead to new prevention. It is therefore crucial to expedite the review and publication of this theory, given its potential implications for public health.

摘要

根据美国国立卫生研究院的一项研究,从不吸烟的个体中,肺癌在女性中更为普遍,且发病年龄比吸烟者更早。女性非吸烟者肺癌发病率的上升可能与吸入氡气有关,应进一步调查。我们的理论基于男性和女性在氡暴露方面的差异,这可归因于在室内和室外度过的时间差异。在过去几年中,美国和其他发达国家的吸烟率呈稳步下降趋势。吸烟率的这种下降导致了与肺癌相关的主要风险因素的新转变。虽然历史上烟草烟雾一直是肺癌的主要原因,但吸烟率的下降使其他风险因素(如氡暴露)走到了前沿。鉴于某些国家的女性平均而言可能比男性在室内花费更多时间,她们可能接触到更高水平的氡。这种增加的暴露可能解释了女性非吸烟者肺癌发病率的上升。该理论仍处于初期阶段,需要进一步研究和验证。然而,如果被证明是正确的,它可能会显著改变我们对肺癌风险因素的理解,并带来新的预防措施。因此,鉴于其对公共卫生的潜在影响,加快对该理论的审查和发表至关重要。

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