Cosialls Raúl, Simó Cristina, Borrós Salvador, Gómez-Vallejo Vanessa, Schmidt Claudia, Llop Jordi, Cuenca Ana B, Casini Angela
BISi-Bonds group, Dept. of Organic and Pharmaceutical Chemistry, Institut Químic de Sarrià, URL, Vía Augusta 390, 08017, Barcelona, Spain.
Department of Organic and Inorganic Chemistry, Universidad del País Vasco (UPV/EHU), Barrio Sarriena s/n, 48940, Leioa, Bizkaia, Spain.
Chemistry. 2023 Jan 12;29(3):e202202604. doi: 10.1002/chem.202202604. Epub 2022 Nov 23.
To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of F-labelled [Pd L ] metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.
为推动自组装金属超分子结构作为新一代诊疗剂的设计，本文报道了含氟标记的[Pd L]金属笼的合成。不同的光谱和生物分析方法证实了主体-客体笼-顺铂复合物的形成。通过PET/CT体内成像并结合体外ICP-MS，研究了其中一种金属笼单独存在或包封顺铂时在健康小鼠体内的生物分布情况。
