State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Adv Healthc Mater. 2021 Jan;10(1):e2001239. doi: 10.1002/adhm.202001239. Epub 2020 Sep 16.
Supramolecular peptide hydrogel (SPH) is a class of biomaterials self-assembled from peptide-based gelators through non-covalent interactions. Among many of its biomedical applications, the potential of SPH in cancer therapy has been vastly explored in the past decade, taking advantage of its good biocompatibility, multifunctionality, and injectability. SPHs can exert localized cancer therapy and induce systemic anticancer immunity to prevent tumor recurrence, depending on the design of SPH. This review first gives a brief introduction to SPH and then outlines the major types of peptide-based gelators that have been developed so far. The methodologies to tune the physicochemical properties and biological activities are summarized. The recent advances of SPH in cancer therapy as carriers, prodrugs, or drugs are highlighted. Finally, the clinical translation potential and main challenges in this field are also discussed.
超分子肽水凝胶（SPH）是一类通过非共价相互作用自组装的基于肽的凝胶因子的生物材料。在其众多的生物医学应用中，SPH 在癌症治疗中的潜力在过去十年中得到了广泛的探索，利用其良好的生物相容性、多功能性和可注射性。SPH 可以根据 SPH 的设计进行局部癌症治疗并诱导全身性抗癌免疫以防止肿瘤复发。本综述首先对 SPH 进行了简要介绍，然后概述了迄今为止开发的主要类型的基于肽的凝胶因子。总结了调节物理化学性质和生物活性的方法。重点介绍了 SPH 在癌症治疗中作为载体、前药或药物的最新进展。最后，还讨论了该领域的临床转化潜力和主要挑战。
