Webb Taylor D, Lybbert Carter, Wilson Matthew G, Odéen Henrik, Kubanek Jan
Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.
Neuromodulation. 2025 Jan;28(1):155-161. doi: 10.1016/j.neurom.2024.07.005. Epub 2024 Aug 22.
Transcranial ultrasound neuromodulation (TUSN) is a noninvasive and spatially specific therapy that promises to deliver treatments tailored to the specific needs of individuals. To fulfill this promise, each treatment must be modified to adequately correct for variation across individual skulls and neural anatomy. This study examines the use of ultrasound-induced voltage potentials (measured with electroencephalography [EEG]) to guide TUSN therapies.
We measured EEG responses in two awake nonhuman primates during sonication of 12 targets surrounding two deep brain nuclei, the left and right lateral geniculate nucleus.
We report reliable ultrasound evoked potentials measured with EEG after the deep brain ultrasonic modulation in nonhuman primates. Robust responses are observed after just ten repetitions of the ultrasonic stimuli. Moreover, these potentials are only evoked for specific deep brain targets. Furthermore, a behavioral study in one subject shows a direct correspondence between the target with maximal EEG response and ultrasound-based modulation of visual choice behavior. Thus, this study provides evidence for the feasibility of EEG-based guidance for ultrasound neuromodulation therapies.
经颅超声神经调节（TUSN）是一种无创且具有空间特异性的治疗方法，有望提供针对个体特定需求的定制治疗。为实现这一承诺，每种治疗都必须进行调整，以充分校正个体颅骨和神经解剖结构的差异。本研究探讨了利用超声诱导电压电位（通过脑电图[EEG]测量）来指导TUSN治疗。
我们在对两个深部脑核（左右外侧膝状体核）周围的12个靶点进行超声处理时，测量了两只清醒的非人类灵长类动物的脑电图反应。
我们报告了在非人类灵长类动物进行深部脑超声调制后，通过脑电图测量到可靠的超声诱发电位。仅经过十次超声刺激重复后就观察到强烈反应。此外，这些电位仅在特定的深部脑靶点诱发。此外，对一只受试动物的行为研究表明，脑电图反应最大的靶点与基于超声的视觉选择行为调制之间存在直接对应关系。因此，本研究为基于脑电图的超声神经调节治疗指导的可行性提供了证据。
