Kumaran Girishkumar, Carroll Liam, Muirhead Nina, Bottomley Matthew J
Chinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Skin Inspection, London, United Kingdom.
J Invest Dermatol. 2025 Mar;145(3):522-535. doi: 10.1016/j.jid.2024.07.006. Epub 2024 Aug 22.
Spatial transcriptomic (ST) profiling is the mapping of gene expression within cell populations with preservation of positional context and represents an exciting new approach to develop our understanding of local and regional influences upon skin biology in health and disease. With the ability to probe from a few hundred transcripts to the entire transcriptome, multiple ST approaches are now widely available. In this paper, we review the ST field and discuss its application to dermatology. Its potential to advance our understanding of skin biology in health and disease is highlighted through the illustrative examples of 3 research areas: cutaneous aging, tumorigenesis, and psoriasis.
空间转录组学（ST）分析是在保留位置背景的情况下对细胞群体内基因表达进行图谱绘制，它代表了一种令人兴奋的新方法，有助于我们深入了解健康和疾病状态下局部和区域因素对皮肤生物学的影响。凭借从数百个转录本到整个转录组进行探测的能力，目前有多种ST方法可供广泛使用。在本文中，我们回顾了ST领域并讨论了其在皮肤病学中的应用。通过皮肤老化、肿瘤发生和银屑病这3个研究领域的实例，突出了其在促进我们对健康和疾病状态下皮肤生物学理解方面的潜力。
