Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, Yunnan, People's Republic of China; Nanjing University of Science and Technology, Nanjing, 650091, Yunnan, People's Republic of China.
College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, 650091, Yunnan, People's Republic of China.
Phytochemistry. 2024 Dec;228:114251. doi: 10.1016/j.phytochem.2024.114251. Epub 2024 Aug 22.
Seven previously undescribed compounds, including one amino acid hybrid sesquiterpene areolatol A (1), two unusual natural sesquiterpenoid skeleton areolatones A-B (2-3) and four benzo[j]fluoranthene areolaranes A-D (4-7) were characterized from Annulohypoxylon areolatum. The structures of the compounds were determined by extensive spectroscopic analysis, X-ray diffraction analysis, and ECD and NMR computational. Notably, areolatol A (1) was the first reported sesquiterpene featuring a 5/7/3-ring system and hybridized with two molecular amino acids. In addition, areolaranes A-D (4-7) were identified as possible chemophenetic markers.
从 Annulohypoxylon areolatum 中分离得到了 7 种以前未描述的化合物，包括一种氨基酸混合倍半萜烯 areolatol A（1）、两种不寻常的天然倍半萜烯骨架 areolatones A-B（2-3）和四种苯并[j]荧蒽 areolaranes A-D（4-7）。通过广泛的光谱分析、X 射线衍射分析以及 ECD 和 NMR 计算确定了化合物的结构。值得注意的是，areolatol A（1）是第一个报道的具有 5/7/3 环系统和两个分子氨基酸的倍半萜烯。此外，还鉴定出 areolaranes A-D（4-7）可能是化学表型标志物。
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