Stephenson M L, Krane S M, Amento E P, McCroskery P A, Byrne M
FEBS Lett. 1985 Jan 21;180(1):43-50. doi: 10.1016/0014-5793(85)80227-1.
Recombinant immune interferon, (interferon-gamma, IFN-gamma) inhibits types I and III collagen synthesis by rheumatoid synovial fibroblast-like cells in culture. This decrease is associated with a decrease in the levels of types I and III procollagen mRNAs in these cells as measured by dot blot hybridization. In the control synovial cells the level of alpha 2(I) mRNA is disproportionately high compared with that of alpha 1(I) or alpha 1(III) mRNA, and IFN-gamma suppresses the level of alpha 1(I) and alpha 1(III) mRNA to a greater extent than that of alpha 2(I) mRNA. The lymphokine, IFN-gamma, may thus have a role in the regulation of collagen synthesis in inflammatory joint disease and other conditions.
重组免疫干扰素（γ干扰素，IFN-γ）可抑制培养的类风湿性滑膜成纤维样细胞中I型和III型胶原蛋白的合成。通过斑点杂交法测定，这种减少与这些细胞中I型和III型前胶原mRNA水平的降低有关。在对照滑膜细胞中，α2（I）mRNA的水平与α1（I）或α1（III）mRNA相比过高，而IFN-γ对α1（I）和α1（III）mRNA水平的抑制程度大于α2（I）mRNA。因此，淋巴因子IFN-γ可能在炎症性关节疾病和其他病症中胶原蛋白合成的调节中发挥作用。
