滑液中的细胞因子：II. 肿瘤坏死因子和干扰素的存在
Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon.
作者信息
Hopkins S J, Meager A
机构信息
University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK.
出版信息
Clin Exp Immunol. 1988 Jul;73(1):88-92.
Abstract
Cytokine-specific monoclonal antibodies were used in enzyme-linked immunoadsorbant assays (ELISA) to examine a variety of synovial fluids for the presence of cytokines which might be expected to play some part in the pathology of arthritis. Low, but significant, levels of tumour necrosis factor alpha (TNF-alpha) were present in the majority of synovial fluids obtained from rheumatoid arthritis patients with a sero-positive history. Low levels of interferon (IFN)-alpha and IFN-gamma were also detected, but only IFN-alpha was significantly increased in the sero-positive group. Tumour necrosis factor beta (TNF-beta) was present only in trace amounts. These results suggest that the presence of cytokines, such as TNF-alpha and IFN-alpha in synovial fluid may be associated with tissue changes observed in rheumatoid joint disease and thus contribute to the pathology of the arthritis, but support evidence for the minimal role likely to be played by IFN-gamma in the joint pathology of rheumatoid arthritis.
摘要
细胞因子特异性单克隆抗体用于酶联免疫吸附测定（ELISA），以检测各种滑液中可能在关节炎病理过程中起一定作用的细胞因子。在大多数有血清阳性病史的类风湿性关节炎患者的滑液中，存在低水平但显著水平的肿瘤坏死因子α（TNF-α）。还检测到低水平的干扰素（IFN）-α和IFN-γ，但仅IFN-α在血清阳性组中显著增加。肿瘤坏死因子β（TNF-β）仅微量存在。这些结果表明，滑液中TNF-α和IFN-α等细胞因子的存在可能与类风湿性关节疾病中观察到的组织变化有关，从而导致关节炎的病理过程，但支持IFN-γ在类风湿性关节炎关节病理中可能起最小作用的证据。
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