Lindemann R A, Newman M G, Kaufman A K, Le T V
J Dent Res. 1985 Jan;64(1):54-7. doi: 10.1177/00220345850640011001.
Microbial samples from the oral cavities of cystic fibrosis (C.F.) patients and 20 age-matched normal control subjects were characterized. Mucoid variant Pseudomonas aeruginosa was isolated from the tongue, buccal mucosa, and saliva of C.F. patients only. Analysis of the data suggests that the oral cavity is a potential reservoir for this organism. Aspiration and cross-contamination from this reservoir may be important in perpetuating chronic pulmonary infection in C.F. patients. Susceptibility testing was performed on 20 mucoid variant P. aeruginosa oral isolates obtained from the patients according to standardized broth dilution procedures. The in vitro antimicrobial effects of sodium fluoride, stannous fluoride, and chlorhexidine were measured. Analysis of the data suggests that clinically safe and achievable levels of chlorhexidine and stannous fluoride may be antimicrobial.
对囊性纤维化（C.F.）患者口腔以及20名年龄匹配的正常对照受试者的微生物样本进行了特征分析。仅从C.F.患者的舌头、颊黏膜和唾液中分离出了黏液样变异铜绿假单胞菌。数据分析表明，口腔是这种微生物的一个潜在储存库。来自该储存库的吸入和交叉污染可能对C.F.患者慢性肺部感染的持续存在很重要。根据标准化肉汤稀释程序，对从患者身上获得的20株黏液样变异铜绿假单胞菌口腔分离株进行了药敏试验。测量了氟化钠、氟化亚锡和洗必泰的体外抗菌效果。数据分析表明，临床上安全且可达到的洗必泰和氟化亚锡水平可能具有抗菌作用。
