Department of Neurology, Jiangxi Provincial People's Hospital, Clinical College of Nanchang Medical College, First Affiliated Hospital of Nanchang Medical College, Xiangya Hospital of Central South University Jiangxi Hospital, National Regional Medical Center for Neurological Diseases, No. 266 Fenghe North Avenue, Honggutan District, Nanchang 330008, Jiangxi, China.
Department of Neurology, Jiangxi Provincial People's Hospital, Clinical College of Nanchang Medical College, First Affiliated Hospital of Nanchang Medical College, Xiangya Hospital of Central South University Jiangxi Hospital, National Regional Medical Center for Neurological Diseases, No. 266 Fenghe North Avenue, Honggutan District, Nanchang 330008, Jiangxi, China.
Epilepsy Behav. 2024 Oct;159:109991. doi: 10.1016/j.yebeh.2024.109991. Epub 2024 Aug 23.
Uric acid (UA) serves as a crucial endogenous antioxidant in the body, offering protection against oxidative stress, whichmaycontributetoepilepsypathogenesis. The association between serum UA levels and epilepsy remains uncertain. This study aimed to examine the potential connections between serum UA levels and epilepsy in US adults.
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018, a cross-sectional analysis was conducted. Weighted logistic regression analyses were employed to assess the potential link between serum UA levels and the risk of epilepsy. Additionally, sensitivity analyses were conducted to evaluate the reliability of the results.
We included 15,373 participants, of whom 136 (0.79 %) had epilepsy. Following adjustment for multiple variables, participants with serum UA levels <4.1 mg/dl had an odds ratio of 2.24 (95 % CI: 1.12-4.47, P = 0.023) for epilepsy compared to those with serum UA levels of 5.8-6.5 mg/dl. The results of the sensitivity analyses corroborated the initial findings.
Our study revealed a significant association between lower serum UA levels and heightened risks of epilepsy, suggesting that low UA levels may serve as an independent risk factor for epilepsy. A marginal increase in UA levels within the normal range may act as a protective factor against epilepsy.
尿酸（UA）是体内重要的内源性抗氧化剂，可抵御氧化应激，而氧化应激可能与癫痫发病机制有关。血清 UA 水平与癫痫之间的关系尚不确定。本研究旨在探讨美国成年人血清 UA 水平与癫痫之间的潜在联系。
利用 2013-2018 年国家健康和营养调查（NHANES）的数据进行横断面分析。采用加权 logistic 回归分析评估血清 UA 水平与癫痫风险之间的潜在关联。此外，还进行了敏感性分析以评估结果的可靠性。
我们纳入了 15373 名参与者，其中 136 名（0.79%）患有癫痫。在调整了多个变量后，血清 UA 水平<4.1mg/dl 的参与者患癫痫的比值比为 2.24（95%CI：1.12-4.47，P=0.023），而血清 UA 水平为 5.8-6.5mg/dl 的参与者为对照。敏感性分析的结果证实了最初的发现。
我们的研究表明，血清 UA 水平较低与癫痫风险增加之间存在显著关联，提示低 UA 水平可能是癫痫的独立危险因素。正常范围内 UA 水平的轻微升高可能是癫痫的保护因素。
