Cardiovascular Department, The Quzhou Affiliated Hospital of Wenzhou Medical University (Quzhou People's Hospital), Quzhou, Zhejiang, 324000, China.
Neurology Department, The Quzhou Affiliated Hospital of Wenzhou Medical University (Quzhou People's Hospital), Quzhou, Zhejiang, 324000, China.
Sci Rep. 2024 Oct 15;14(1):24097. doi: 10.1038/s41598-024-74869-5.
This study explores the relationship between serum uric acid(UA) levels and depression. UA is the final product of purine metabolism in the human body, possessing certain physiological functions such as blood pressure regulation, antioxidation, DNA protection, and anti-aging, thereby drawing attention for its potential role in preventing and treating depression.
This cross-sectional study includes 32,424 participants aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018, generating a nationally representative database. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Serum uric acid concentration was measured using the uricase-peroxidase coupled method, and participants were divided into quartiles of serum uric acid concentration. Weighted data were calculated according to analysis guidelines. The association between serum uric acid and depressive symptoms was analyzed using weighted multivariable logistic regression models and restricted cubic spline regression analyses. Subgroup analyses were also performed.
Among 32,424 participants, 3,421 were defined as having depressive symptoms. The crude prevalence of depressive symptoms was 10.5% (weighted prevalence: 9.086% [95% confidence interval: 9.032-9.139%]). Compared with the first quartile, individuals with higher UA levels had a decreased risk of depressive symptoms by 9% (OR: 0.910, 95% CI: 0.797-10.40), 14.6% (OR: 0.854, 95% CI: 0.741-0.983), and 20.5% (OR: 7795, 95% CI: 0.680-0.930), respectively. Further restricted cubic spline regression analysis revealed a nonlinear association between UA and depressive symptoms, with an inflection point of 319.72 µmol/L. Subgroup multivariable weighted logistic regression analysis found that the association between UA and the risk of depressive symptoms remained consistent across all subgroups, demonstrating high stability and reliability.
This study emphasizes a significant nonlinear negative correlation between serum uric acid and depressive symptoms. This suggests that proper control of serum uric acid levels may play a role in preventing and treating depression.
本研究探讨了血清尿酸（UA）水平与抑郁之间的关系。UA 是人体嘌呤代谢的终产物，具有调节血压、抗氧化、保护 DNA 和抗衰老等一定的生理功能，因此其在预防和治疗抑郁方面的潜在作用引起了关注。
本横断面研究纳入了 2005 年至 2018 年期间进行的国家健康和营养检查调查（NHANES）中 32424 名年龄≥20 岁的参与者，生成了一个具有全国代表性的数据库。抑郁症状采用患者健康问卷-9 进行评估。采用尿酸酶-过氧化物酶偶联法测定血清尿酸浓度，并将参与者分为血清尿酸浓度四分位组。根据分析指南计算加权数据。采用加权多变量逻辑回归模型和限制立方样条回归分析来分析血清尿酸与抑郁症状之间的关系。还进行了亚组分析。
在 32424 名参与者中，有 3421 人被诊断为患有抑郁症状。抑郁症状的粗患病率为 10.5%（加权患病率：9.086%[95%置信区间：9.032-9.139%]）。与第一四分位数相比，UA 水平较高的个体抑郁症状的风险降低了 9%（OR：0.910，95%CI：0.797-10.40）、14.6%（OR：0.854，95%CI：0.741-0.983）和 20.5%（OR：0.7795，95%CI：0.680-0.930）。进一步的限制立方样条回归分析显示，UA 与抑郁症状之间存在非线性关系，拐点为 319.72µmol/L。亚组多变量加权逻辑回归分析发现，UA 与抑郁症状风险之间的关联在所有亚组中均保持一致，表明其具有较高的稳定性和可靠性。
本研究强调了血清尿酸与抑郁症状之间存在显著的非线性负相关。这表明适当控制血清尿酸水平可能在预防和治疗抑郁方面发挥作用。
