咪唑并[1,5-a]吡啶类：一类新型血栓素A2合成酶抑制剂。
Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors.
作者信息
Ford N F, Browne L J, Campbell T, Gemenden C, Goldstein R, Gude C, Wasley J W
出版信息
J Med Chem. 1985 Feb;28(2):164-70. doi: 10.1021/jm00380a003.
PMID:3918169
Abstract
The synthesis and structure-activity profile of a new class of potent and highly specific thromboxane A2 synthetase inhibitors is described. The most potent member of this series in vitro is determined to be imidazo[1,5-a]-pyridine-5-hexanoic acid (9).
摘要
描述了一类新型强效且高度特异性血栓素A2合成酶抑制剂的合成及其构效关系。该系列中体外活性最强的成员被确定为咪唑并[1,5-a]吡啶-5-己酸（9）。
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