School of Health Sciences, Jaramogi Oginga Odinga University of Science and Technology, Bondo, Kenya.
Laboratory of cell biology and histology, University of Antwerp, Antwerp, Belgium.
BMC Womens Health. 2024 Aug 24;24(1):468. doi: 10.1186/s12905-024-03303-9.
Persistent human papillomavirus (HPV) infection is considered the primary etiological factor for invasive cervical cancer. Understanding the epidemiology of circulating potential high-risk (HR) and HR HPV strains is essential in updating epidemiological knowledge and recommendations on genotype-specific vaccination development. This study determined the prevalence and factors associated with Potential HR/HR HPV among women attending selected reproductive health clinics in Lake Victoria Basin.
A cross-sectional facility-based survey made up of 434 women aged 16-68 years was carried out in two selected facilities. Structured questionnaires were administered to collect participant clinical and social characteristics. Cervical specimens were collected and HPV genotyping was carried out using RIATOL HPV genotyping qPCR assay. Descriptive statistics followed by logistic binary regression was done using R version 4.3.2.
The overall prevalence of potential HR/HR HPV among women attending the selected reproductive health clinics was reported at 36.5% (158/434). Specifically, in the rural setting, Gobei Health Center, the prevalence was 41.4% (41/99) while in the urban setting-JOOTRH, it was 34.6% (117/335). The most prevalent potential HR/HR HPV are 52, 67, 16, 31, 39, 45, and 31 among women. Age was the main factor associated with HPV infection with women between the age of 30-39 having the highest risk (AOR = 0.3, CI:0.2-0.7, p < 0.001).
In both rural and urban regions, potential HR/HR HPV infection among women attending reproductive health clinics at the selected facilities remains common. The study identifies the need for effective implementation and clinical follow-up process of cervical cancer control program in the LVB.
持续性人乳头瘤病毒（HPV）感染被认为是浸润性宫颈癌的主要病因。了解循环潜在高危（HR）和 HR HPV 毒株的流行病学情况对于更新流行病学知识和制定基于基因型的疫苗接种建议至关重要。本研究旨在确定在维多利亚湖盆地选定生殖健康诊所就诊的女性中潜在 HR/HR HPV 的流行情况及其相关因素。
在两个选定的医疗机构中开展了一项横断面的基于设施的调查，共纳入了 434 名年龄在 16-68 岁的女性。采用问卷调查收集参与者的临床和社会特征。采集宫颈标本，采用 RIATOL HPV 基因分型 qPCR 法进行 HPV 基因分型。采用 R 版本 4.3.2 进行描述性统计和逻辑二元回归分析。
在参加选定生殖健康诊所的女性中，潜在 HR/HR HPV 的总体流行率为 36.5%（158/434）。具体而言，在农村的 Gobei 保健中心，其流行率为 41.4%（41/99），而在城市的 JOOTRH，其流行率为 34.6%（117/335）。最常见的潜在 HR/HR HPV 包括 52、67、16、31、39、45 和 31。年龄是 HPV 感染的主要相关因素，30-39 岁的女性感染风险最高（AOR=0.3，95%CI：0.2-0.7，p<0.001）。
在农村和城市地区，参加选定医疗机构生殖健康诊所的女性中，潜在 HR/HR HPV 感染仍然很常见。该研究表明，在 LVB 需要有效实施和临床随访宫颈癌控制计划。
