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肯尼亚的人乳头瘤病毒疫苗接种:面临的挑战及提高接种率的策略

HPV Vaccination in Kenya: The Challenges Faced and Strategies to Increase Uptake.

作者信息

Karanja-Chege Christine Muthoni

机构信息

Kenyatta University, Nairobi, Kenya.

出版信息

Front Public Health. 2022 Mar 21;10:802947. doi: 10.3389/fpubh.2022.802947. eCollection 2022.

Abstract

Human papilloma virus (HPV) is the leading cause of ano-genital cancers globally with cervical cancer as the top cause of cancer- related deaths in women. Over 90% of these deaths occur in low income countries where cancer control strategies remain inadequate. HPV vaccination provides protection against HPV types 16 and 18 which are responsible for approximately 70% of cervical cancer cases. The optimal age of vaccination is in the early adolescent period, before sexual debut with possible HPV infection. Studies have shown that children residing in low income settlements are at risk of early initiation of sexual activity. Adolescent vaccination programs would provide an avenue to link other health promotion strategies targeting this age group that has hitherto been left out of many health interventions in 2019, Kenya introduced HPV vaccine to be given to 10 year old girls. Uptake has been sub-optimal with only 33% of targeted population receiving the first dose in 2020 and 16% returning for the 2nd dose. While disruption of immunization programs by the COVID-19 pandemic contributed to the low coverage, other factors such as low demand fuelled by misinformation have also played a role.

摘要

人乳头瘤病毒(HPV)是全球肛门生殖器癌症的主要病因,宫颈癌是女性癌症相关死亡的首要原因。这些死亡中超过90%发生在癌症控制策略仍然不足的低收入国家。HPV疫苗接种可预防16型和18型HPV,这两种类型导致了约70%的宫颈癌病例。最佳接种年龄是青春期早期,即首次性行为且可能感染HPV之前。研究表明,居住在低收入社区的儿童有过早开始性行为的风险。青少年疫苗接种计划将提供一条途径,以关联针对这一年龄组的其他健康促进策略,而该年龄组在2019年之前一直被许多健康干预措施所忽视。肯尼亚于2019年引入HPV疫苗,接种对象为10岁女孩。疫苗接种率一直不理想,2020年只有33%的目标人群接种了第一剂,16%的人回来接种第二剂。虽然新冠疫情导致免疫计划中断是覆盖率低的原因之一,但其他因素,如错误信息导致的需求低,也起到了作用。

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