Department of Intensive Care Unit, Linping Campus, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 311100, Zhejiang, China.
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Ann Clin Microbiol Antimicrob. 2024 Aug 24;23(1):80. doi: 10.1186/s12941-024-00728-w.
Due to the increasing emergence of antibiotic resistance in Enterococcus faecalis (E. faecalis), it indicated as potentially opportunistic pathogen causing various healthcare-associated and life-threatening diseases around the world.
The aim of this meta-analysis was to evaluate the weighted pooled resistance rates in clinical E. faecalis isolates based on over time, areas, antimicrobial susceptibility testing (AST), and infection source.
We searched the studies in PubMed, Scopus, and Web of Science (November 30, 2022). All statistical analyses were carried out using the statistical package R.
The analysis encompassed a total of 74 studies conducted in 28 countries. According to the meta-regression, the chloramphenicol, fosfomycin, imipenem, linezolid, minocycline, norfloxacin, quinupristin-dalfopristin, and tetracycline resistance rate increased over time. Analysis revealed statistically significant differences in antibiotic resistance rates for ampicillin, chloramphenicol, erythromycin, gentamicin, penicillin, rifampicin, teicoplanin, tetracycline, and vancomycin across various countries.
Globally, the prevalence of drug resistant E. faecalis strains are on the increase over time. Daptomycin and tigecycline can be an effective agent for the treatment of clinical E. faecalis infections. Considering the low prevalence of antibiotic resistance in continents of Europe and Australia, it is suggested to take advantage of their preventive strategies in order to obtain efficient results in other places with high prevalence of resistance.
由于屎肠球菌（E. faecalis）对抗生素的耐药性不断增加，它已成为全球范围内引发各种医疗相关和危及生命疾病的潜在机会性病原体。
本荟萃分析旨在评估屎肠球菌临床分离株随时间、地域、抗菌药物敏感性试验（AST）和感染源变化的耐药率。
我们在 PubMed、Scopus 和 Web of Science 中检索了截至 2022 年 11 月 30 日的研究。所有统计分析均使用 R 统计软件包进行。
该分析共纳入了 28 个国家的 74 项研究。meta 回归分析表明，氯霉素、磷霉素、亚胺培南、利奈唑胺、米诺环素、诺氟沙星、奎奴普丁-达福普汀和四环素的耐药率随时间推移而增加。分析显示，在不同国家，氨苄西林、氯霉素、红霉素、庆大霉素、青霉素、利福平、替考拉宁、四环素和万古霉素的抗生素耐药率存在统计学差异。
全球范围内，屎肠球菌耐药株的流行率随时间呈上升趋势。达托霉素和替加环素可作为治疗屎肠球菌临床感染的有效药物。鉴于欧洲和澳大利亚大陆抗生素耐药率较低，建议利用这些地区的预防策略，在耐药率较高的其他地区获得有效的结果。
