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用于加法性角膜移植的 SMILE 术后基质透镜保存：眼库面临的新挑战？

Banking of post-SMILE stromal lenticules for additive keratoplasty: A new challenge for eye banks?

机构信息

Fondazione Banca Degli Occhi del Veneto, Via Paccagnella, 11, 30174, Venice, Italy.

Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, 030167, Bucharest, Romania.

出版信息

Int Ophthalmol. 2024 Aug 25;44(1):355. doi: 10.1007/s10792-024-03283-7.

DOI:10.1007/s10792-024-03283-7
PMID:39182212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11345333/
Abstract

PURPOSE

ReLEx (Refractive Lenticule Extraction) Small Incision Lenticule Extraction (SMILE), the second generation of ReLEx Femtosecond Lenticule Extraction (FLEx), is a minimally invasive, flapless procedure designed to treat refractive errors such as myopia, hyperopia, presbyopia, and astigmatism. This review aims to provide a comprehensive overview of the methods for preserving SMILE-derived lenticules and discusses their potential future applications.

METHODS

A narrative literature review was conducted using PubMed, Scopus, and Web of Science databases, focusing on articles published up to January 2024 and available in English. The authors also evaluated the reference lists of the collected papers to identify any additional relevant research.

RESULTS

No standardized protocols currently exist for the storage or clinical application of SMILE-derived lenticules. However, these lenticules present a promising resource for therapeutic uses, particularly in addressing the shortage of donor corneal tissues. Their potential applications include inlay and overlay additive keratoplasty, as well as other ocular surface applications. Further research is needed to establish reliable protocols for their preservation and clinical use.

CONCLUSION

SMILE-derived lenticules offer significant potential as an alternative to donor corneal tissues. Standardizing their storage and application methods could enhance their use in clinical settings.

摘要

目的

ReLEx（折射性微透镜提取）小切口微透镜提取（SMILE）是 ReLEx 飞秒微透镜提取（FLEx）的第二代产品，是一种微创、无瓣的手术，旨在治疗近视、远视、老视和散光等屈光不正。本综述旨在全面概述保存 SMILE 衍生微透镜的方法，并讨论其潜在的未来应用。

方法

使用 PubMed、Scopus 和 Web of Science 数据库进行叙述性文献综述，重点关注截至 2024 年 1 月发表的英文文章，并评估收集论文的参考文献以确定任何其他相关研究。

结果

目前尚无用于保存 SMILE 衍生微透镜的标准化方案，也没有临床应用方案。然而，这些微透镜为治疗用途提供了一个有前途的资源，特别是在解决供体角膜组织短缺的问题上。它们的潜在应用包括镶嵌和覆盖性附加性角膜成形术，以及其他眼表面应用。需要进一步的研究来建立可靠的保存和临床应用方案。

结论

SMILE 衍生微透镜作为供体角膜组织的替代物具有很大的潜力。标准化其存储和应用方法可以增强它们在临床环境中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/8965d8f65d05/10792_2024_3283_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/0675b76320ba/10792_2024_3283_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/cd8da352b341/10792_2024_3283_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/b1899a3731b0/10792_2024_3283_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/8965d8f65d05/10792_2024_3283_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/0675b76320ba/10792_2024_3283_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/cd8da352b341/10792_2024_3283_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/b1899a3731b0/10792_2024_3283_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72a6/11345333/8965d8f65d05/10792_2024_3283_Fig4_HTML.jpg

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本文引用的文献

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Something to SMILE about. Is small incision lenticule extraction (SMILE) ready to become the gold standard in laser refractive surgery? no.值得一笑的事。小切口基质透镜切除术（SMILE）准备好成为激光屈光手术的金标准了吗？还没有。
Eye (Lond). 2024 Mar;38(4):633-635. doi: 10.1038/s41433-023-02746-y. Epub 2023 Sep 20.
2
Management of keratoconus: an updated review.圆锥角膜的管理：最新综述。
Front Med (Lausanne). 2023 Jun 20;10:1212314. doi: 10.3389/fmed.2023.1212314. eCollection 2023.
3
New insights in presbyopia: impact of correction strategies.
老视新认识：矫正策略的影响。
BMJ Open Ophthalmol. 2023 Jan;8(1). doi: 10.1136/bmjophth-2022-001122.
4
Update of Research Progress on Small Incision Lenticule Extraction (SMILE) Lenticule Reuse.小切口基质透镜切除术（SMILE）透镜再利用的研究进展更新
Clin Ophthalmol. 2023 May 22;17:1423-1431. doi: 10.2147/OPTH.S409014. eCollection 2023.
5
SMILE lenticule versus amniotic membrane graft (AMG) augmented with platelet-rich plasma (PRP) for the treatment of perforated corneal ulcer.SMILE 微透镜与富含血小板的纤维蛋白（PRP）增强的羊膜移植物（AMG）治疗穿透性角膜溃疡。
Int Ophthalmol. 2023 Jul;43(7):2341-2348. doi: 10.1007/s10792-023-02631-3. Epub 2023 Jan 24.
6
Foreword - Orthokeratology for Myopia Control in everyday practice.前言——日常实践中的角膜塑形术控制近视
Cont Lens Anterior Eye. 2023 Feb;46(1):101798. doi: 10.1016/j.clae.2022.101798. Epub 2022 Dec 19.
7
Meniscus-Shaped Stromal Lenticule Addition Keratoplasty for Corneal Regularization and Thickening in Advanced Keratoconus.新月形基质透镜角膜内添加术治疗晚期圆锥角膜的角膜规则化和增厚。
Cornea. 2023 Oct 1;42(10):1221-1228. doi: 10.1097/ICO.0000000000003144. Epub 2022 Sep 16.
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