Zhuang Guo-Bin, Li Xiang, Wu Shi-Nan, Zhang Si-Qi, Zhang Zhi-Jie, Dong Nuo
Department of Ophthalmology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
Eye Institute and Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Front Nutr. 2024 Aug 9;11:1406147. doi: 10.3389/fnut.2024.1406147. eCollection 2024.
This investigation aims to elucidate the correlations between dietary intakes of vitamin E, B6, and niacin and the incidence of cataracts, utilizing the comprehensive NHANES 2005-2008 dataset to affirm the prophylactic roles of these nutrients against cataract formation.
Using data from the NHANES 2005-2008 cycles, this analysis concentrated on 7,247 subjects after exclusion based on incomplete dietary or cataract data. The identification of cataracts was determined through participants' self-reported ophthalmic surgical history. Nutritional intake was gauged using the automated multiple pass method, and the data were analyzed using logistic and quantile regression analyses to investigate the relationship between vitamin consumption and cataract prevalence.
Our analysis identified significant inverse associations between the intake of vitamins E, B6, and niacin and the risk of cataract development. Specifically, higher intakes of vitamin B6 (OR = 0.85, 95% CI = 0.76-0.96, = 0.0073) and niacin (OR = 0.98, 95% CI = 0.97-1.00, = 0.0067) in the top quartile were significantly associated with a reduced likelihood of cataract occurrence. Vitamin E intake showed a consistent reduction in cataract risk across different intake levels (OR = 0.96, 95% CI = 0.94-0.99, = 0.0087), demonstrating a nonlinear inverse correlation.
The outcomes indicate that elevated consumption of vitamin B6 and niacin, in conjunction with regular vitamin E intake, may have the potential to delay or prevent cataract genesis. These results suggest a novel nutritional strategy for cataract prevention and management, advocating that focused nutrient supplementation could be instrumental in preserving eye health and reducing the risk of cataracts. Further research is recommended to validate these findings and establish optimal dosages for maximum benefit.
本研究旨在利用2005 - 2008年美国国家健康与营养检查调查（NHANES）的综合数据集，阐明维生素E、B6和烟酸的膳食摄入量与白内障发病率之间的相关性，以证实这些营养素对预防白内障形成的作用。
利用2005 - 2008年NHANES周期的数据，在排除饮食或白内障数据不完整的受试者后，本分析集中于7247名受试者。通过参与者自我报告的眼科手术史来确定白内障。使用自动多次通过法测量营养摄入量，并使用逻辑回归和分位数回归分析来研究维生素摄入量与白内障患病率之间的关系。
我们的分析发现维生素E、B6和烟酸的摄入量与白内障发生风险之间存在显著的负相关。具体而言，处于最高四分位数的较高维生素B6摄入量（OR = 0.85，95% CI = 0.76 - 0.96，P = 0.0073）和烟酸摄入量（OR = 0.98，95% CI = 0.97 - 1.00，P = 0.0067）与白内障发生可能性降低显著相关。维生素E摄入量在不同摄入水平上均显示白内障风险持续降低（OR = 0.96，95% CI = 0.94 - 0.99，P = 0.0087），呈现非线性负相关。
结果表明，增加维生素B6和烟酸的摄入量，同时定期摄入维生素E，可能有潜力延缓或预防白内障的发生。这些结果提示了一种新的预防和管理白内障的营养策略，主张有针对性的营养补充可能有助于维护眼部健康并降低白内障风险。建议进一步研究以验证这些发现并确定最大获益的最佳剂量。
