Iinuma Shin, Kobayashi Takahiro, Fujiki Yuto
Dermatology, Japanese Red Cross Kitami Hospital, Kitami, JPN.
Dermatology, Asahikawa Medical University, Asahikawa, JPN.
Cureus. 2024 Jul 26;16(7):e65428. doi: 10.7759/cureus.65428. eCollection 2024 Jul.
Dermal melanocytosis includes various congenital and acquired pigmentary disorders characterized by dermal dendritic melanocytes. Blue nevi typically present as papulonodular lesions, whereas other dermal melanocytoses manifest as patches. This report describes a case of a blue nevus associated with acquired dermal melanocytosis on the back of a 46-year-old Japanese woman. The patient presented with a black nodule on a blue-greyish hyperpigmented area on the upper back. Histopathological analysis of the nodule confirmed a common blue nevus, whereas the adjacent hyperpigmented area showed features consistent with acquired dermal melanocytosis. Blue nevi and acquired dermal melanocytoses share a common pathophysiology involving ectopic melanocyte accumulation during embryogenesis. The coexistence of blue nevus and acquired dermal melanocytosis on the back is rare, highlighting the broad spectrum of dermal melanocytosis and the variability of its clinical manifestations. Recognition of such unusual presentations is critical for appropriate diagnosis and management.
皮肤黑素细胞增多症包括各种先天性和后天性色素沉着障碍,其特征为真皮树突状黑素细胞。蓝痣通常表现为丘疹结节性病变,而其他皮肤黑素细胞增多症则表现为斑片。本报告描述了一名46岁日本女性背部出现的与后天性皮肤黑素细胞增多症相关的蓝痣病例。患者上背部蓝灰色色素沉着区域出现一个黑色结节。对该结节的组织病理学分析证实为普通蓝痣,而相邻的色素沉着区域表现出与后天性皮肤黑素细胞增多症相符的特征。蓝痣和后天性皮肤黑素细胞增多症具有共同的病理生理学,涉及胚胎发育过程中异位黑素细胞的积聚。背部蓝痣与后天性皮肤黑素细胞增多症并存的情况罕见,这凸显了皮肤黑素细胞增多症的广泛谱系及其临床表现的变异性。认识到这种不寻常的表现对于正确的诊断和管理至关重要。