Ahmed Yahya Azeem, Naeem Iqra, Bhatti Samee Javed, Shah Badar U Din, Zafar Adnan Ahmad, Ahmed Adeel, Jamil Muhammad Irfan
Nephrology, Nishtar Medical University, Multan, PAK.
Psychiatry and Behavioral Sciences, Lahore General Hospital, Lahore, PAK.
Cureus. 2024 Jul 26;16(7):e65459. doi: 10.7759/cureus.65459. eCollection 2024 Jul.
This study aimed to evaluate the quality of life (QoL) in end-stage kidney disease (ESRD) patients on maintenance hemodialysis through the Missoula-Vitas Quality of Life Index-15 (MVQOLI-15) to identify factors affecting their well-being.
A cross-sectional study was conducted at the Dialysis Unit of the Nephrology Department, Nishtar Hospital Multan. Over six months, 140 eligible patients were enrolled using non-probability consecutive sampling. Participants aged 18-80 years on maintenance hemodialysis for at least six months were evaluated using the MVQOLI-15 questionnaire assessing symptoms, function, interpersonal, well-being, and transcendence dimensions of QoL. Data were analyzed using the IBM SPSS Statistics for Windows, Version 26 (Released 2019; IBM Corp., Armonk, New York). Inferential statistical tests, including the t-test for comparing two groups and analysis of variance (ANOVA) for comparing multiple groups, were utilized to determine the significance of differences in QoL scores among different demographic and clinical categories. P-values less than 0.05 were considered statistically significant.
The study analyzed 140 hemodialysis patients, with a mean age of 52.41 ± 16.31 years and an average hemodialysis duration of 4.55 ± 2.46 years. Most participants were aged 61-80 years (35.7%), had secondary education (44.3%), and were married (67.1%). QoL scores, measured using the MVQOLI, indicated mean values for symptoms at 4.51 ± 10.71, function at 5.77 ± 8.04, interpersonal at 7.49 ± 13.67, well-being at -13.60 ± 7.11, transcendence at 8.24 ± 13.12, and a total score of 16.24 ± 2.75. Significant findings include the following: females had higher symptom scores (p=0.001) and lower well-being scores (p=0.000); younger patients (<30 years) had higher function scores (p=0.054); patients on hemodialysis three times per week had higher function scores (p=0.006); patients taking 1 to 3 pills per day had higher transcendence scores (p=0.000); unmarried patients had higher symptoms scores (p=0.064) and lower well-being scores (p=0.004); and illiterate patients had higher symptoms (p=0.005) and transcendence scores (p=0.034). In total score, patients on hemodialysis once per week reported significantly better scores (p=0.011).
This study highlights varied QoL experiences among hemodialysis patients, with transcendence scoring the highest and well-being, the lowest. Demographic factors such as age, gender, and education level significantly impact the QoL dimensions. Understanding these findings can guide personalized interventions to improve the well-being of hemodialysis patients.
本研究旨在通过米苏拉-维塔斯生活质量指数-15（MVQOLI-15）评估维持性血液透析的终末期肾病（ESRD）患者的生活质量（QoL），以确定影响其幸福感的因素。
在木尔坦尼什塔尔医院肾病科透析单元进行了一项横断面研究。在六个月的时间里，采用非概率连续抽样法招募了140名符合条件的患者。使用MVQOLI-15问卷对年龄在18 - 80岁、接受维持性血液透析至少六个月的参与者进行评估，该问卷评估了生活质量的症状、功能、人际、幸福感和超越维度。使用IBM SPSS Statistics for Windows，版本26（2019年发布；IBM公司，纽约州阿蒙克）对数据进行分析。采用推断性统计检验，包括用于比较两组的t检验和用于比较多组的方差分析（ANOVA），以确定不同人口统计学和临床类别之间生活质量得分差异的显著性。P值小于0.05被认为具有统计学显著性。
该研究分析了140名血液透析患者，平均年龄为52.41±16.31岁，平均血液透析时长为4.55±2.46年。大多数参与者年龄在61 - 80岁（35.7%），接受过中等教育（44.3%），且已婚（67.1%）。使用MVQOLI测量的生活质量得分显示，症状的平均值为4.51±10.71，功能为5.77±8.04，人际为7.49±13.67，幸福感为 - 13.60±7.11，超越为8.24±13.12，总分是16.24±2.75。显著发现如下：女性的症状得分较高（p = 0.001），幸福感得分较低（p = 0.000）；年龄较小的患者（<30岁）功能得分较高（p = 0.054）；每周进行三次血液透析的患者功能得分较高（p = 0.006）；每天服用1至3片药的患者超越得分较高（p = 0.000）；未婚患者症状得分较高（p = 0.064），幸福感得分较低（p = 0.004）；文盲患者症状（p = 0.005）和超越得分较高（p = 0.034）。在总分方面，每周进行一次血液透析的患者得分显著更高（p = 0.011）。
本研究突出了血液透析患者不同的生活质量体验，其中超越得分最高，幸福感得分最低。年龄、性别和教育水平等人口统计学因素对生活质量维度有显著影响。了解这些发现可为改善血液透析患者幸福感的个性化干预提供指导。
